Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Smretschnig, E; Hagen, S; Gamper, J; Krebs, I; Binder, S; Ansari-Shahrezaei, S.
Long-term follow-up of half-fluence photodynamic therapy in acute central serous chorioretinopathy
SPEKTRUM AUGENHEILKD. 2018; 32(6): 215-222.
Doi: 10.1007/s00717-018-0412-y
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- Co-Autor*innen der Med Uni Graz
- Ansari Shahrezaei Siamak
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- Abstract:
- Background To evaluate the long-termresults of indocyanine green angiography(ICGA)-guided verteporfin (Visudyne (R), Novartis, Basel, Switzerland) photodynamic therapy (PDT) with half-fluence rate in the treatment of acute symptomatic central serous chorioretinopathy (CSC). Material and methods A retrospective review was performed of 12 patients with acute symptomatic CSC verified by spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA), treated with ICGA-guided verteporfin (6 mg/m(2))PDT with half-fluence rate (25 J/cm(2)). The vision-related quality of life (VR QOL) 25-Item National Eye Institute Visual Function Questionnaire (VFQ-25) was completed by all patients and 82 controls. Results Best corrected visual acuity (BCVA) at baseline was 77.5 (+/- 10; n=12) according to the Early Treatment Diabetic Retinopathy Study (EDTRS) letter score and changed to 89 letters (+/- 9.9; p=0.0003) at long-term follow-up (83.8 +/- 4.8 months after PDT). Baseline contrast sensitivity (CS) was 29.5 +/- 4.5 Pelli-Robson letters and increased to 34.5 +/- 4.5 letters at long term (p < 0.0006). Baseline central foveal thickness (CFT) was 419 mu m and decreased to 242 mu m at long term (p < 0.0001). The long-term vision-related quality of life of patients was similar to that of controls. Conclusion ICGA-guided half-fluence PDT with verteporfin results in excellent long-term visual improvement in BCVA and CS, a significant reduction of CFT, and high levels of VR QOL.
- Find related publications in this database (Keywords)
- Central serous chorioretinopathy
- Indocyanine green angiography
- Photodynamic therapy
- National Eye Institute Visual Function Questionnaire
- Long term outcome