Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
König, A; Bode, C; Bugger, H.
Diabetes mellitus and myocardial mitochondrial dysfunction: bench to bedside.
Heart Fail Clin. 2012; 8(4): 551-561.
Doi: 10.1016/j.hfc.2012.06.001
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Bugger Heiko Matthias
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- Abstract:
- In diabetics, the risk for development of heart failure is increased even after adjusting for coronary artery disease and hypertension. Although the cause of this increased heart failure risk is multifactorial, increasing evidence suggests that dysfunction of myocardial mitochondria represents an important pathogenetic factor. To date, no specific therapy exists to treat mitochondrial function in any cardiac disease. This article presents underlying mechanisms of mitochondrial dysfunction in the diabetic heart and discusses potential therapeutic options that may attenuate these mitochondrial derangements. Copyright © 2012 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Antioxidants - therapeutic use
- Diabetes Mellitus, Type 2 - complications
- Diabetes Mellitus, Type 2 - drug therapy
- Diabetes Mellitus, Type 2 - pathology
- Heart Failure - drug therapy
- Heart Failure - etiology
- Humans -
- Mitochondria - metabolism
- Mitochondria - pathology
- Mitochondrial Diseases - complications
- Mitochondrial Diseases - drug therapy
- Mitochondrial Diseases - pathology
- Myocardium - metabolism
- Myocardium - pathology
- Oxidative Stress -
- Risk Assessment - methods
- Find related publications in this database (Keywords)
- Mitochondria
- Diabetic cardiomyopathy
- Diabetes
- Antioxidants
- Metabolic therapy