Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Koentges, C; König, A; Pfeil, K; Hölscher, ME; Schnick, T; Wende, AR; Schrepper, A; Cimolai, MC; Kersting, S; Hoffmann, MM; Asal, J; Osterholt, M; Odening, KE; Doenst, T; Hein, L; Abel, ED; Bode, C; Bugger, H.
Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1.
Basic Res Cardiol. 2015; 110(4): 37-37.
Doi: 10.1007/s00395-015-0495-4
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Bugger Heiko Matthias
- Co-Autor*innen der Med Uni Graz
- Pfeil Katharina
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- Abstract:
- Hypoadiponectinemia is an independent predictor of cardiovascular disease, impairs mitochondrial function in skeletal muscle, and has been linked to the pathogenesis of Type 2 diabetes. In models of Type 2 diabetes, myocardial mitochondrial function is impaired, which is improved by increasing serum adiponectin levels. We aimed to define the roles of adiponectin receptor 1 (AdipoR1) and 2 (AdipoR2) in adiponectin-evoked regulation of mitochondrial function in the heart. In isolated working hearts in mice lacking AdipoR1, myocardial oxygen consumption was increased without a concomitant increase in cardiac work, resulting in reduced cardiac efficiency. Activities of mitochondrial oxidative phosphorylation (OXPHOS) complexes were reduced, accompanied by reduced OXPHOS protein levels, phosphorylation of AMP-activated protein kinase, sirtuin 1 activity, and peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) signaling. Decreased ATP/O ratios suggested myocardial mitochondrial uncoupling in AdipoR1-deficient mice, which was normalized by lowering increased mitochondrial 4-hydroxynonenal levels following treatment with the mitochondria-targeted antioxidant Mn (III) tetrakis (4-benzoic acid) porphyrin. Lack of AdipoR2 did not impair mitochondrial function and coupling in the heart. Thus, lack of AdipoR1 impairs myocardial mitochondrial function and coupling, suggesting that impaired AdipoR1 signaling may contribute to mitochondrial dysfunction and mitochondrial uncoupling in Type 2 diabetic hearts.
- Find related publications in this database (using NLM MeSH Indexing)
- AMP-Activated Protein Kinases - physiology
- Animals -
- Male -
- Mice -
- Mice, Inbred C57BL -
- Mitochondria, Heart - physiology
- Myocardial Contraction -
- Oxidative Phosphorylation -
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha -
- Reactive Oxygen Species - metabolism
- Receptors, Adiponectin - physiology
- Sirtuin 1 - physiology
- Transcription Factors - physiology
- Find related publications in this database (Keywords)
- Adiponectin receptor
- Mitochondria
- Heart