Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bugger, H; Abel, ED.
Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome.
Clin Sci (Lond). 2008; 114(3): 195-210.
Doi: 10.1042/CS20070166
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Bugger Heiko Matthias
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- Abstract:
- The metabolic syndrome represents a cluster of abnormalities, including obesity, insulin resistance, dyslipidaemia and Type 2 diabetes, that increases the risk of developing cardiovascular diseases, such as coronary artery disease and heart failure. The heart failure risk is increased even after adjusting for coronary artery disease and hypertension, and evidence is emerging that changes in cardiac energy metabolism might contribute to the development of contractile dysfunction. Recent findings suggest that myocardial mitochondrial dysfunction may play an important role in the pathogenesis of cardiac contractile dysfunction in obesity, insulin resistance and Type 2 diabetes. This review will discuss potential molecular mechanisms for these mitochondrial abnormalities.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcium - metabolism
- Disease Models, Animal -
- Fatty Acids - metabolism
- Humans -
- Insulin Resistance -
- Metabolic Syndrome - physiopathology
- Mice -
- Mitochondria, Heart - physiology
- Mitochondrial Myopathies - physiopathology
- Oxidation-Reduction -
- Oxidative Stress -
- Rats -
- Find related publications in this database (Keywords)
- diabetes
- energy metabolism
- metabolic syndrome
- mitochondrial dysfuction
- oxidative stress
- uncoupling protein (UCP)