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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Zittermann, A; Ernst, JB; Prokop, S; Fuchs, U; Dreier, J; Kuhn, J; Knabbe, C; Börgermann, J; Berthold, HK; Pilz, S; Gouni-Berthold, I; Gummert, JF.
Daily Supplementation with 4000 IU Vitamin D3 for Three Years Does Not Modify Cardiovascular Risk Markers in Patients with Advanced Heart Failure: The Effect of Vitamin D on Mortality in Heart Failure Trial.
Ann Nutr Metab. 2019; 74(1):62-68 Doi: 10.1159/000495662
Web of Science PubMed FullText FullText_MUG

Co-Autor*innen der Med Uni Graz: Pilz Stefan
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Abstract:: We aimed to investigate the effect of a moderately high vitamin D dose on lipid parameters and biochemical markers of vascular calcification (VC) in patients with established cardiovascular disease. We included in this pre-specified secondary analysis of a randomized controlled trial 161 patients with advanced heart failure and 25-hydroxyvitamin D (25OHD) concentrations < 75 nmol/L (vitamin D group: n = 80; placebo group: n = 81), who received a daily vitamin D3 supplement of 4,000 IU for 3 years. We assessed between-group differences of the lipid parameters total-cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, and triglycerides, and the VC markers fetuin-A and non-phosphorylated undercarboxylated matrix gla protein (MGP) at study termination, with adjustment for baseline values. Lipid parameters, the percentage of patients with dyslipoproteinemia, and VC markers did not differ significantly between groups at study termination (p values: 0.395-0.939). Likewise, vitamin D achieved no significant treatment effect on these markers in subgroup analyses in patients with 25OHD concentrations < 30 nmol/L, nonusers of lipid-lowering drugs, or diabetic patients (p values: 0.245-0.998). Our data indicate that vitamin D does not improve the lipid profile and does not influence the calcification inhibitors fetuin-A and non-phosphorylated undercarboxylated MGP in patients with advanced heart failure. © 2018 S. Karger AG, Basel.
Find related publications in this database (Keywords): Vitamin D; Cardiovascular risk markers; Dyslipoproteinemia; Fetuin-A; Matrix-gla-protein