Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Theiler-Schwetz, V; Zaufel, A; Schlager, H; Obermayer-Pietsch, B; Fickert, P; Zollner, G.
Bile acids and glucocorticoid metabolism in health and disease.
Biochim Biophys Acta Mol Basis Dis. 2019; 1865(1):243-251
Doi: 10.1016/j.bbadis.2018.08.001
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- Führende Autor*innen der Med Uni Graz
- Theiler-Schwetz Verena
- Zollner Gernot
- Co-Autor*innen der Med Uni Graz
- Fickert Peter
- Obermayer-Pietsch Barbara
- Schlager Hansjörg
- Zaufel Alex
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- Abstract:
- Glucocorticoids are regulators of stress response essential for survival. Liver disease can alter this homeostatic mechanism in patients with liver cirrhosis - a finding that might mirror the controversially discussed condition of critical illness related corticosteroid insufficiency. Underlying mechanisms might be shared molecular pathways in both bile acid as well as glucocorticoid metabolism at the level of synthesis, catabolism or the hypothalamus and the pituitary gland. Molecular links include the farnesoid X receptor FXR or the G protein-coupled bile acid receptor TGR5 expressed in the liver and the adrenals. In this review we sum up knowledge on the regulation of adrenal gland function and steroidogenesis, focussing on bile acids and potential alterations under cholestatic conditions, depict molecular links between glucocorticoid and bile acid metabolism and discuss the difficulties of assessment of adrenal function in humans in general and more specifically in liver diseases.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenal Glands - metabolism
- Bile Acids and Salts - metabolism
- Cholestasis - metabolism
- Corticosterone - metabolism
- Fibrosis - metabolism
- Glucocorticoids - metabolism
- Homeostasis - administration & dosage
- Hormones - biosynthesis
- Humans - administration & dosage
- Hydrocortisone - blood, metabolism, urine
- Lipid Metabolism - administration & dosage
- Liver - metabolism
- Liver Cirrhosis - metabolism
- Liver Diseases - blood, diagnosis, metabolism, urine
- Liver Diseases, Alcoholic - metabolism
- Receptors, G-Protein-Coupled - metabolism
- Steroids - metabolism
- Find related publications in this database (Keywords)
- Cortisol
- Corticosterone
- Steroids
- Glucocorticoids
- Adrenal gland
- Cholestasis
- Cirrhosis
- Relative adrenal insufficiency
- Critical illness-related corticosteroid insufficiency