Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lambert, M; Capuano, V; Olschewski, A; Sabourin, J; Nagaraj, C; Girerd, B; Weatherald, J; Humbert, M; Antigny, F.
Ion Channels in Pulmonary Hypertension: A Therapeutic Interest?
INT J MOL SCI. 2018; 19(10):
Doi: 10.3390/ijms19103162
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Chandran Nagaraj
- Olschewski Andrea
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- Abstract:
- Pulmonary arterial hypertension (PAH) is a multifactorial and severe disease without curative therapies. PAH pathobiology involves altered pulmonary arterial tone, endothelial dysfunction, distal pulmonary vessel remodeling, and inflammation, which could all depend on ion channel activities (K⁺, Ca2+, Na⁺ and Cl-). This review focuses on ion channels in the pulmonary vasculature and discusses their pathophysiological contribution to PAH as well as their therapeutic potential in PAH.
- Find related publications in this database (Keywords)
- PAH
- TRPC
- Orai
- K+ channels
- KCNK3
- TMEM16A
- Na+ channels
- pulmonary hypertension