Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Margonis, GA; Buettner, S; Andreatos, N; Wagner, D; Sasaki, K; Galjart, B; Kamphues, C; Pawlik, TM; Poultsides, G; Kaczirek, K; Lønning, PE; Verhoef, C; Kreis, ME; Wolfgang, CL; Weiss, MJ.
The prognosis of colorectal cancer liver metastases associated with inflammatory bowel disease: An exploratory analysis.
J Surg Oncol. 2018; 118(7):1074-1080
Doi: 10.1002/jso.25251
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Wagner Doris
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- In contrast with sporadic colorectal cancer liver metastases (CRLM), inflammatory bowel disease (IBD)-related CRLM have not been studied to date. Patients who underwent resection for IBD-related and sporadic CRLM from 2000 to 2015 were identified from an international registry and matched for pertinent prognostic variables. Overall survival (OS) and recurrence-free survival (RFS) were subsequently assessed. Twenty-eight patients had IBD-related CRLM. Synchronous extrahepatic disease was more common in IBD-related CRLM patients than patients with sporadic CRLM (28.6% vs 8.3%; P < 0.001), most commonly located in the lungs. In multivariable analysis, IBD did not have a significant influence on OS ( P = 0.835), and had a hazard ratio (HR) close to 1 (HR, 0.95; 95% confidence interval [CI], 0.57-1.57). IBD was also not associated with inferior RFS (HR, 1.07; 95%CI, 0.68-1.68; P = 0.780). Among patients with IBD-related CRLM, 9(50%) had isolated intrahepatic recurrence and 8(44.4%) isolated extrahepatic recurrence, while only 1(5.6%) developed combined recurrence. Of those who experienced recurrence after resection of IBD-related CRLM, 10 had their recurrence treated with curative intent. Patients with IBD-related CRLM had similar survival compared with patients with sporadic CRLM, even though they more often present with extrahepatic disease. In addition, patients with IBD-related CRLM may experience patterns of recurrence different from patients with sporadic CRLM. © 2018 Wiley Periodicals, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Colorectal Neoplasms - pathology
- Europe - epidemiology
- Female -
- Follow-Up Studies -
- Hepatectomy -
- Humans -
- Inflammatory Bowel Diseases - epidemiology
- Liver Neoplasms - mortality
- Liver Neoplasms - secondary
- Liver Neoplasms - therapy
- Lung Neoplasms -
- Lymphatic Metastasis -
- Male -
- Middle Aged -
- Multivariate Analysis -
- Mutation -
- Neoplasm Recurrence, Local -
- Pancreatic Neoplasms -
- Peritoneal Neoplasms -
- Prognosis -
- Proto-Oncogene Proteins p21(ras) - genetics
- Retrospective Studies -
- United States - epidemiology
- Find related publications in this database (Keywords)
- colorectal liver metastases (CRLM)
- inflammatory bowel disease (IBD)
- overall survival (OS)
- recurrence