Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wang, VY; Niestrawska, JA; Wilson, AJ; Sands, GB; Young, AA; LeGrice, IJ; Nash, MP.
Image-driven constitutive modeling of myocardial fibrosis
INT J COMPUT METH EN. 2016; 17(3): 211-221.
Doi: 10.1080/15502287.2015.1082675
Web of Science
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- Co-Autor*innen der Med Uni Graz
- Niestrawska Justyna Anna
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- Abstract:
- Myocardial fibrosis is a pathological process that occurs during heart failure (HF). It involves microstructural remodeling of normal myocardial tissue, and consequent changes in both cardiac geometry and function. The role of myocardial structural remodeling in the progression of HF remains poorly understood. We propose a constitutive modeling framework, informed by high-resolution images of cardiac tissue structure, to model the mechanical response of normal and fibrotic myocardium. This image-driven constitutive modeling approach allows us to better reproduce and understand the relationship between structural and functional remodeling of ventricular myocardium during HF.
- Find related publications in this database (Keywords)
- Confocal imaging
- constitutive properties
- diastolic heart failure
- finite element modeling
- myocardial fibrosis