Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pagonas, N; Gross, CM; Li, M; Bondke, A; Klauss, V; Buschmann, EE.
Influence of epicardial stenosis severity and central venous pressure on the index of microcirculatory resistance in a follow-up study.
EuroIntervention. 2014; 9(9): 1063-1068.
Doi: 10.4244/EIJV9I9A180
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Buschmann Eva Elina
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- Abstract:
- This study sought to evaluate the reproducibility of the index of microcirculatory resistance (IMR) in a follow-up model and the role of epicardial artery stenosis and central venous pressure (Pv) on IMR. Twenty-two patients with stable coronary artery disease underwent coronary catheterisation at baseline and after seven weeks. The IMR was calculated at baseline and follow-up in several ways: as IMRuncorrected=Pd·Tmn (Pd: intracoronary pressure distal to the stenosis; Tmn: transit mean time); IMRcorrected=Pa·Tmn·(Pd - Pw)/(Pa-Pw), (Pw: coronary wedge pressure; Pa: aortic pressure); and as IMRcentral venous pressure (IMRcvp)=(Pa-Pv)·Tmn·(Pd-Pw)/(Pa-Pw). By neglecting Pw, IMR was overestimated irrespective of the haemodynamic severity of the epicardial stenosis (baseline: IMRuncorrected=15.5±8.9 U vs. IMRcorrected=13.5±8 U, p<0.001; follow-up: IMRuncorrected=16.9±4.9 U vs. IMRcorrected=13.8±4.6 U, p<0.001). In the intra-individual analysis IMR did not differ between the two time points. The IMRcvp equalled the IMRcorrected at all time points. IMR is a reproducible index in follow-up studies, independent of any overestimation existing when collateral flow status is neglected. Pv can be neglected for calculation of the IMR.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Central Venous Pressure - physiology
- Collateral Circulation - physiology
- Coronary Circulation - physiology
- Coronary Stenosis - surgery
- Coronary Vessels - surgery
- Female -
- Follow-Up Studies -
- Humans -
- Male -
- Microcirculation - physiology
- Middle Aged -
- Severity of Illness Index -
- Vascular Resistance - physiology
- Find related publications in this database (Keywords)
- collateral circulation
- fractional flow reserve
- ischaemic heart disease
- microcirculation