Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Jungehuelsing, GJ; Liman, TG; Brunecker, P; Ebel, A; Endres, M; Buschmann, I; Pagonas, N; Buschmann, EE; Arteriogenesis Network; Center for Stroke Research Berlin.
Does external counterpulsation augment mean cerebral blood flow in the healthy brain? Effects of external counterpulsation on middle cerebral artery flow velocity and cerebrovascular regulatory response in healthy subjects.
Cerebrovasc Dis. 2010; 30(6): 612-617.
Doi: 10.1159/000319891
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Buschmann Eva Elina
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- Abstract:
- External counterpulsation (ECP) noninvasively improves myocardial and organ perfusion via diastolic augmentation. The effects on cerebral blood flow velocities (CBFV) and hemodynamics are controversial. In this study, the effect of active ECP treatment on CBF in healthy subjects was continuously measured. In 9 healthy volunteers (mean age 34.1 ± 11.1 years, 4 females), 20-min active ECP treatment was performed. CBFV in the middle cerebral artery were detected via transcranial Doppler. CBFV were registered continuously before, during and after ECP. The protocol was repeated twice. At onset of ECP, immediate changes in CBFV were observed: peak diastolic blood flow velocities increased from baseline to treatment (63 vs. 76 cm/s; p < 0.001) and diastolic blood flow augmentation was maintained throughout ECP. Peak systolic (87 vs. 78 cm/s; p < 0.001) and end-diastolic velocities (40 vs. 28 cm/s; p < 0.001) decreased significantly, while mean CBFV maintained constant (59 vs. 58 cm/s; not significant). The pulsatility index and resistance index as indirect parameters for peripheral vascular resistance increased during ECP (pulsatility index 0.79 vs. 0.89, p < 0.001; resistance index 0.54 vs. 0.64; p < 0.001). ECP did not increase mean CBFV in healthy subjects even though peak diastolic CBFV were significantly augmented. Changes in CBFV and transcranial Doppler waveform characteristics suggest that the mean flow of the middle cerebral artery is maintained stable via cerebrovascular autoregulatory mechanisms. Copyright © 2010 S. Karger AG, Basel.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Blood Flow Velocity -
- Cerebrovascular Circulation -
- Counterpulsation -
- Female -
- Germany -
- Homeostasis -
- Humans -
- Male -
- Middle Cerebral Artery - diagnostic imaging
- Middle Cerebral Artery - physiology
- Pulsatile Flow -
- Regional Blood Flow -
- Time Factors -
- Ultrasonography, Doppler, Transcranial -
- Vascular Resistance -
- Young Adult -
- Find related publications in this database (Keywords)
- External counterpulsation
- Cerebral blood flow
- Autoregulation
- Transcranial Doppler