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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Aberer, F; Lichtenegger, KM; Smajic, E; Donsa, K; Malle, O; Samonigg, J; Höll, B; Beck, P; Pieber, TR; Plank, J; Mader, JK.
GlucoTab-guided insulin therapy using insulin glargine U300 enables glycaemic control with low risk of hypoglycaemia in hospitalized patients with type 2 diabetes.
Diabetes Obes Metab. 2019; 21(3):584-591
Doi: 10.1111/dom.13559
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- Leading authors Med Uni Graz
- Aberer Felix
- Lichtenegger Katharina
- Co-authors Med Uni Graz
- Höll Bernhard
- Mader Julia
- Malle Oliver
- Pieber Thomas
- Samonigg Judith
- Smajic Edin
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- Abstract:
- To investigate efficacy, safety and usability of the GlucoTab system for glycaemic management using insulin glargine U300 in non-critically ill hospitalized patients with type 2 diabetes (T2D). In this open, non-controlled single-arm pilot study, glycaemic control at the general ward of a tertiary care hospital was guided by a mobile decision support system (GlucoTab) for basal-bolus insulin dosing using the novel basal insulin analogue insulin glargine U300 for the first time. Glycaemic control was surveilled with capillary glucose measurements and continuous glucose monitoring (CGM). The primary endpoint was efficacy of glycaemic management, defined as the percentage of blood glucose measurements within the target range of 3.9 to 7.8 mmol/L. A total of 30 patients with T2D (12 female; age, 67 ± 11 years; HbA1c, 70 ± 26 mmol/mol; BMI, 31.8 ± 5.6 kg/m2 ; length of study, 8.5 ± 4.5 days) were included. In total, 894 capillary glucose values and 49 846 data points of CGM were available, of which 56.1% of all measured capillary glucose values and 54.3% of CGM values were within the target area (3.9-7.8 mmol/L). Overall capillary mean glucose was 8.5 ± 1.2 and 8.4 ± 1.2 mmol/L assessed by CGM. Time within glucose target improved continuously during the course of treatment, while time within hypoglycaemia (<3.9 mmol/L) decreased substantially. The GlucoTab-suggested total daily dose was accepted by staff in 97.3% of situations. Treatment with GlucoTab using insulin glargine U300 in hospitalized patients with T2D is effective and safe. © 2018 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.
- Find related publications in this database (Keywords)
- basal bolus insulin therapy
- decision support system
- inpatient diabetes management
- insulin glargine U300
- type 2 diabetes