Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Anto Michel, N; Colberg, C; Buscher, K; Sommer, B; Pramod, AB; Ehinger, E; Dufner, B; Hoppe, N; Pfeiffer, K; Marchini, T; Willecke, F; Stachon, P; Hilgendorf, I; Heidt, T; von Zur Muhlen, C; von Elverfeldt, D; Pfeifer, D; Schüle, R; Kintscher, U; Brachs, S; Ley, K; Bode, C; Zirlik, A; Wolf, D.
Inflammatory Pathways Regulated by Tumor Necrosis Receptor-Associated Factor 1 Protect From Metabolic Consequences in Diet-Induced Obesity.
Circ Res. 2018; 122(5):693-700
Doi: 10.1161/CIRCRESAHA.117.312055
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- Leading authors Med Uni Graz
- Anto Michel Nathaly
- Zirlik Andreas
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- Abstract:
- The coincidence of inflammation and metabolic derangements in obese adipose tissue has sparked the concept of met-inflammation. Previous observations, however, suggest that inflammatory pathways may not ultimately cause dysmetabolism. We have revisited the relationship between inflammation and metabolism by testing the role of TRAF (tumor necrosis receptor-associated factor)-1, an inhibitory adapter of inflammatory signaling of TNF (tumor necrosis factor)-α, IL (interleukin)-1β, and TLRs (toll-like receptors). Mice deficient for TRAF-1, which is expressed in obese adipocytes and adipose tissue lymphocytes, caused an expected hyperinflammatory phenotype in adipose tissue with enhanced adipokine and chemokine expression, increased leukocyte accumulation, and potentiated proinflammatory signaling in macrophages and adipocytes in a mouse model of diet-induced obesity. Unexpectedly, TRAF-1-/- mice were protected from metabolic derangements and adipocyte growth, failed to gain weight, and showed improved insulin resistance-an effect caused by increased lipid breakdown in adipocytes and UCP (uncoupling protein)-1-enabled thermogenesis. TRAF-1-dependent catabolic and proinflammatory cues were synergistically driven by β3-adrenergic and inflammatory signaling and required the presence of both TRAF-1-deficient adipocytes and macrophages. In human obesity, TRAF-1-dependent genes were upregulated. Enhancing TRAF-1-dependent inflammatory pathways in a gain-of-function approach protected from metabolic derangements in diet-induced obesity. These findings identify TRAF-1 as a regulator of dysmetabolism in mice and humans and question the pathogenic role of chronic inflammation in metabolism. © 2018 American Heart Association, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipocytes - metabolism
- Animals -
- Cells, Cultured -
- Diet, High-Fat - adverse effects
- Insulin Resistance -
- Lipid Metabolism -
- Male -
- Mice -
- Mice, Inbred C57BL -
- Obesity - etiology
- Obesity - genetics
- Obesity - metabolism
- TNF Receptor-Associated Factor 1 - genetics
- Thermogenesis -
- Uncoupling Protein 1 - metabolism
- Find related publications in this database (Keywords)
- adipocytes
- lipolysis
- metabolic syndrome
- mice
- obesity