Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zirlik, A; Lutgens, E.
An inflammatory link in atherosclerosis and obesity. Co-stimulatory molecules.
HAMOSTASEOLOGIE. 2015; 35(3): 272-278.
Doi: 10.5482/HAMO-14-12-0079
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Zirlik Andreas
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- Abstract:
- Atherosclerosis and obesity-induced metabolic dysfunction are lipid-driven inflammatory pathologies responsible for a major part of cardiovascular complications. Immune cell activation as well as interactions between the different immune cells is dependent on and controlled by a variety of co-stimulatory signals. These co-stimulatory signals can either aggravate or ameliorate the disease depending on the stage of the disease, the cell-types involved and the signal transduction cascades initiated. This review focuses on the diverse roles of the most established co-stimulatory molecules of the B7 and Tumor Necrosis Factor Receptor (TNFR) families, ie the CD28/CTLA4-CD80/CD86 and CD40L/CD40 dyads in the pathogenesis of atherosclerosis and obesity. In addition, we will explore their potential as therapeutic targets in both atherosclerosis and obesity.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Atherosclerosis - immunology
- Cytokines - immunology
- Humans -
- Immunity, Innate - immunology
- Inflammation Mediators - immunology
- Lipid Metabolism - immunology
- Models, Immunological -
- Obesity - immunology
- Signal Transduction - immunology
- Find related publications in this database (Keywords)
- Atherosclerosis
- obesity
- co-stimulation