Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zirlik, A; Abdullah, SM; Gerdes, N; MacFarlane, L; Schönbeck, U; Khera, A; McGuire, DK; Vega, GL; Grundy, S; Libby, P; de Lemos, JA.
Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis: results from the Dallas Heart Study.
ARTERIOSCL THROM VAS. 2007; 27(9): 2043-2049.
Doi: 10.1161/ATVBAHA.107.149484
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- Führende Autor*innen der Med Uni Graz
- Zirlik Andreas
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- Abstract:
- Although IL-18 promotes atherogenesis in animal studies and predicts cardiovascular risk in humans, it is unknown whether elevated IL-18 levels are associated with coronary atherosclerosis in the general population. IL-18 plasma levels were determined by ELISA in 2231 subjects from the Dallas Heart Study. In univariable analysis, IL-18 levels associated with traditional cardiovascular risk factors and particularly with components of the metabolic syndrome (MS, P<0.01 for trend across the number of MS components); IL-18 also associated with coronary artery calcium (CAC) scores measured by electron beam computed tomography and aortic plaque measured by MRI (P<0.01 for each). In multivariable analyses, IL-18 remained associated with multiple components of the MS but not with CAC or aortic plaque. In a large population-based sample, elevated IL-18 plasma levels associated with risk factors for atherosclerosis and with the metabolic syndrome. The association between IL-18 and atherosclerosis diminished after accounting for traditional cardiovascular risk factors. These data suggest that IL-18 does not add independently to detection of atherosclerotic burden in asymptomatic individuals.
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- Adult -
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