Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zirlik, A; Leugers, A; Lohrmann, J; Ernst, S; Sobel, BE; Bode, C; Nordt, TK.
Direct attenuation of plasminogen activator inhibitor type-1 expression in human adipose tissue by thiazolidinediones.
THROMB HAEMOSTASIS. 2004; 91(4): 674-682.
Doi: 10.1160/TH03-06-0384
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- Führende Autor*innen der Med Uni Graz
- Zirlik Andreas
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- Abstract:
- Adipose tissue produces substantial amounts of plasminogen activator inhibitor type-1 (PAI-1), an established cardiovascular risk factor. This study evaluated PAI-1 expression in human adipose tissue in response to thiazolidinediones, insulin sensitising drugs activating peroxisome proliferator-activated receptor-gamma (PPAR-gamma). Troglitazone, rosiglitazone, and ciglitazone significantly reduced PAI-1 protein expression in human preadipocytes under basal conditions and after stimulation of the cells with TGF-beta. Pioglitazone had no effect. In human adipocytes all four thiazolidinediones significantly attenuated PAI-1 expression. Signalling appeared to be mediated via PPAR-gamma and effects reflected, at least in part, changes in transcription. Accordingly, patients with insulin resistance may benefit from treatment with thiazolidinediones with respect to diminution of PAI-1 expression in adipose tissue and consequent potential reduction of cardiovascular risk.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipocytes - cytology
- Adipocytes - drug effects
- Adipose Tissue - cytology
- Adipose Tissue - drug effects
- Adipose Tissue - metabolism
- Cells, Cultured -
- Chromans - pharmacology
- Humans -
- Hypoglycemic Agents - pharmacology
- Insulin Resistance -
- PPAR gamma - metabolism
- Plasminogen Activator Inhibitor 1 - analysis
- Plasminogen Activator Inhibitor 1 - biosynthesis
- Thiazolidinediones - pharmacology
- Transcription, Genetic -
- Find related publications in this database (Keywords)
- PAI-I
- adipose tissue
- PPAR-gamma
- coronary heart disease
- diabetes mellitus