Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wolf, D; Stachon, P; Bode, C; Zirlik, A.
Inflammatory mechanisms in atherosclerosis.
HAMOSTASEOLOGIE. 2014; 34(1): 63-71.
Doi: 10.5482/HAMO-13-09-0050
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Zirlik Andreas
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- Abstract:
- Throughout the last two decades inflammation has been recognized as the central mechanism underlying atherogenesis. A multitude of basic science work demonstrates the pivotal role of inflammatory processes during every step of atherosclerotic plaque formation: From initiation via propagation to complication. This review describes some of the key mechanisms involved with a particular focus on the diverse group of inflammatory cells and their subsets that distinctly contribute to atherogenic and anti-atherogenic phenomena. Furthermore, we summarize the controlling action of a tight network of co-stimulatory molecules and cytokines orchestrating the inflammatory and anti-inflammatory effector functions. Finally, the current status of clinical trials evaluating anti-inflammatory/immune-modulatory treatment strategies is summarized and an outlook for future therapeutic implications is provided.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Atherosclerosis - immunology
- Blood Vessels - immunology
- Cytokines - immunology
- Humans -
- Immunity, Innate - immunology
- Immunologic Factors - immunology
- Inflammation - immunology
- Models, Cardiovascular -
- Models, Immunological -
- Find related publications in this database (Keywords)
- Atherosclerosis
- inflammation
- mechanisms
- inflammatory cells
- clinical trials