Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gugatschka, M; Jarvis, JC; Perkins, JD; Bubalo, V; Wiederstein-Grasser, I; Lanmüller, H; Gerstenberger, C; Karbiener, M.
Functional Electrical Stimulation Leads to Increased Volume of the Aged Thyroarytenoid Muscle.
Laryngoscope. 2018; 128(12):2852-2857
Doi: 10.1002/lary.27342
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- Führende Autor*innen der Med Uni Graz
- Gugatschka Markus
- Co-Autor*innen der Med Uni Graz
- Bubalo Vladimir
- Gerstenberger Claus
- Karbiener Michael
- Wiederstein-Grasser Iris
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- Abstract:
- To reverse sarcopenia and increase the volumes of atrophied laryngeal muscles by functional electrical stimulation (FES) using a minimal invasive surgical procedure in an aged ovine model. Prospective animal study. A stimulation electrode was placed unilaterally near the terminal adduction branch of the recurrent laryngeal nerve (RLN) adjacent to the right cricothyroid joint. The electrode was connected to an implant located subcutaneously at the neck region. Predesigned training patterns were automatically delivered by a bidirectional radio frequency link using a programming device and were repeated automatically by the implant every other day over 11 weeks in the awake animal. Outcome parameters comprised volumetric measurements based on three-dimensional reconstructions of the entire thyroarytenoid muscle (TAM), as well as gene expression analyses. We found significant increases of the volumes of the stimulated TAM of 11% and the TAM diameter at the midmembranous parts of the vocal folds of nearly 40%. Based on gene expression, we did not detect a shift of muscle fiber composition. FES of the terminal branches of the RLN is a secure and effective way to reverse the effects of age-related TAM atrophy and to increase volumes of atrophied muscles. NA Laryngoscope, 128:2852-2857, 2018. © 2018 The Authors. The Laryngoscope published by Wiley Periodicals, Inc. on behalf of The American Laryngological, Rhinological and Otological Society, Inc, “The Triological Society” and American Laryngological Association (ALA).
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Disease Models, Animal -
- Electric Stimulation - methods
- Female -
- Imaging, Three-Dimensional -
- Laryngeal Muscles - diagnostic imaging
- Laryngeal Muscles - innervation
- Prospective Studies -
- Recurrent Laryngeal Nerve - physiopathology
- Sheep -
- Vocal Cord Paralysis - diagnosis
- Vocal Cord Paralysis - therapy
- Find related publications in this database (Keywords)
- Aged larynx
- functional electrical stimulation
- glottal gap
- vocal fold atrophy