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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Aberer, F; Mader, JK; Holzgruber, J; Trummer, C; Schwetz, V; Pandis, M; Pferschy, PN; Greinix, H; Tripolt, NJ; Pieber, TR; Zebisch, A; Sill, H; Wölfler, A; Sourij, H.
Feasibility and safety of using an automated decision support system for insulin therapy in the treatment of steroid-induced hyperglycemia in patients with acute graft-versus-host disease: A randomized trial.
J Diabetes Investig. 2019; 10(2):339-342
Doi: 10.1111/jdi.12919
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- Leading authors Med Uni Graz
- Aberer Felix
- Co-authors Med Uni Graz
- Greinix Hildegard
- Mader Julia
- Pandis Marlene
- Pferschy Peter
- Pieber Thomas
- Sill Heinz
- Sourij Harald
- Theiler-Schwetz Verena
- Tripolt Norbert
- Trummer Christian
- Wölfler Albert
- Zebisch Armin
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- Abstract:
- Steroid-induced hyperglycemia (SIHG) has shown to independently increase the risk for mortality in patients with acute graft-versus-host disease, and it is still unclear whether SIHG might be a modifiable risk factor. Therefore, a feasibility trial was carried out aiming to evaluate the performance of a standardized decision support system (GlucoTab [GT]) for insulin therapy in patients with SIHG. A total of 10 hyperglycemic acute graft-versus-host disease patients were included and treated either with GT or standard of care during hospitalization. Follow-up duration was 6 months. Comparing the GT versus standard of care group, 364 versus 1,020 glucose readings were available during a median of 41 days (interquartile range [IQR] 22-89) and 101 days (IQR 55-147) of hospitalization. The median overall glucose levels were 151 mg/dL (123-192) versus 162 mg/dL (IQR 138-193) for GT and standard of care, respectively (P < 0.001); hypoglycemia rates were comparably low. Treatment of SIHG with an algorithm-based system for subcutaneous insulin was feasible and safe. © 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
- Find related publications in this database (Keywords)
- Decision support system
- Feasibility trial
- Steroid-induced hyperglycemia