Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Alijotas-Reig, J; Ferrer-Oliveras, R; Esteve-Valverde, E; Ruffatti, A; Tincani, A; Lefkou, E; Bertero, MT; Espinosa, G; Coloma, E; de Carolis, S; Rovere-Querini, P; Canti, V; Picardo, E; Fredi, M; Mekinian, A; EUROAPS Study Group.
Inherited thrombophilia in women with poor aPL-related obstetric history: prevalence and outcomes. Survey of 208 cases from the European Registry on Obstetric Antiphospholipid Syndrome cohort.
Am J Reprod Immunol. 2016; 76(2): 164-171.
Doi: 10.1111/aji.12534
Web of Science
PubMed
FullText
FullText_MUG
- Study Group Mitglieder der Med Uni Graz:
- Mayer-Pickel Karoline Ilse
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- To analyse the prevalence and effects of inherited thrombophilic disorders (ITD) on maternal-foetal outcomes in cases of antiphospholipid antibody related to obstetric complications. Women with obstetric complaints who tested positive for aPL and with inherited thrombophilia were prospectively and retrospectively included. ITD data were available in 208 of 338: 147 had obstetric antiphospholipid syndrome (OAPS) and 61 aPL-related obstetric morbidity (OMAPS). 24.1% had ITD. Laboratory categories I and IIa were more related to OAPS-ITD and IIb and IIc to OMAPS-ITD. No significant differences in obstetric complaints were observed. Regarding ITD carriers, treatment rates were higher in OAPS than in OMAPS for LMWH and LDA plus LMWH (P=.002). Cases with aPL-related OAPS/OMAPS showed no differences in maternal-foetal outcomes regardless of the presence of one ITD. Maternal thrombotic risk was low, with ITD-positive cases included. Registry data concur with Sydney criteria, whereby aPL-ITD-positive patients are classified as having antiphospholipid syndrome. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antiphospholipid Syndrome - complications
- Antiphospholipid Syndrome - epidemiology
- Europe - epidemiology
- Female -
- Humans -
- Pregnancy -
- Pregnancy Complications, Hematologic - epidemiology
- Pregnancy Outcome - epidemiology
- Prevalence -
- Registries -
- Thrombophilia - complications
- Thrombophilia - epidemiology
- Find related publications in this database (Keywords)
- antiphospholipid antibody
- inherited thrombophilia
- obstetric outcome
- thrombosis
- treatment