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SHR Neuro Cancer Cardio Lipid Metab Microb

Franolić, I; Bedenić, B; Beader, N; Lukić-Grlić, A; Mihaljević, S; Bielen, L; Zarfel, G; Meštrović, T.
NDM-1-producing Enterobacter aerogenes isolated from a patient with a JJ ureteric stent in situ.
CEN Case Rep. 2019; 8(1):38-41 Doi: 10.1007/s13730-018-0360-z [OPEN ACCESS]
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Co-authors Med Uni Graz: Zarfel Gernot
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Abstract:: Urinary tract infections after JJ stent insertion are among the most common complications, and the associated microorganisms carry more antibiotic resistance determinants than those found in urine prior to stent insertion. In line with the trends in healthcare epidemiology which implicate multi-resistant microorganisms in a plethora of healthcare-associated infections, prosthetic stent material also represents an ideal milieu for biofilm formation and subsequent infection development with resistant bacterial agents. Here we describe a case of a 73-year-old Caucasian woman presenting with urinary tract infection after JJ ureteric stent insertion due to ureteric obstruction and hydronephrosis of her left kidney. Extensive microbiological work-up and comprehensive molecular analysis identified the putative microorganism as carbapenem-resistant Enterobacter aerogenes carrying New Delhi metallo-beta-lactamase 1 (NDM-1). This is a first literature report implicating such extensively resistant strain of this species in early indwelling ureteric stent complications, and also the first report of NDM-1 in Enterobacter aerogenes in Croatia and Europe.
Find related publications in this database (Keywords): Enterobacter aerogenes; NDM-1; Antimicrobial resistance; JJ stent; Ureteric obstruction