Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Cinotti, E; Labeille, B; Debarbieux, S; Carrera, C; Lacarrubba, F; Witkowski, AM; Moscarella, E; Arzberger, E; Kittler, H; Bahadoran, P; Gonzalez, S; Guitera, P; Agozzino, M; Farnetani, F; Hofmann-Wellenhof, R; Ardigò, M; Rubegni, P; Tognetti, L; Łudzik, J; Zalaudek, I; Argenziano, G; Longo, C; Ribero, S; Malvehy, J; Pellacani, G; Cambazard, F; Perrot, JL.
Dermoscopy vs. reflectance confocal microscopy for the diagnosis of lentigo maligna.
J Eur Acad Dermatol Venereol. 2018; 32(8):1284-1291
Doi: 10.1111/jdv.14791
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Arzberger Edith Johanna
- Hofmann-Wellenhof Rainer
- Zalaudek Iris
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- Abstract:
- BACKGROUND: Several dermoscopic and in vivo reflectance confocal microscopy (RCM) diagnostic criteria of lentigo maligna (LM)/lentigo maligna melanoma (LMM) have been identified. However, no study compared the diagnostic accuracy of these techniques. OBJECTIVE: We evaluated the diagnostic accuracy of dermoscopy and RCM for LM/LMM using a holistic assessment of the images. METHODS: A total of 223 facial lesions were evaluated by 21 experts. Diagnostic accuracy of the clinical, dermoscopic and RCM examination was compared. Interinvestigator variability and confidence level in the diagnosis were also evaluated. RESULTS: Overall diagnostic accuracy of the two imaging techniques was good (area under the curve of the sROC function: 0.89). RCM was more sensitive (80%, vs. 61%) and less specific (81% vs. 92%) than dermoscopy for LM/LMM. In particular, RCM showed a higher sensitivity for hypomelanotic and recurrent LM/LMM. RCM had a higher interinvestigator agreement and a higher confidence level in the diagnosis than dermoscopy. CONCLUSION: Reflectance confocal microscopy and dermoscopy are both useful techniques for the diagnosis of facial lesions and in particular LM/LMM. RCM is particularly suitable for the identification of hypomelanotic and recurrent LM/LMM.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Aged - administration & dosage
- Aged, 80 and over - administration & dosage
- Area Under Curve - administration & dosage
- Dermoscopy - administration & dosage
- Facial Neoplasms - diagnostic imaging
- Female - administration & dosage
- Humans - administration & dosage
- Hutchinson's Melanotic Freckle - diagnostic imaging
- Male - administration & dosage
- Microscopy, Confocal - administration & dosage
- Middle Aged - administration & dosage
- Observer Variation - administration & dosage
- ROC Curve - administration & dosage
- Reproducibility of Results - administration & dosage
- Skin Neoplasms - diagnostic imaging