Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Jakovic, L; Gotic, M; Gisslinger, H; Soldatovic, I; Sefer, D; Tirnanic, M; Lekovic, D; Jovanovic, MP; Schalling, M; Gisslinger, B; Beham-Schmid, C; Simonitsch-Klupp, I; Thiele, J.
The WHO diagnostic criteria for polycythemia vera-role of red cell mass versus hemoglobin/hematocrit level and morphology.
Ann Hematol. 2018; 97(9):1581-1590
Doi: 10.1007/s00277-018-3344-3
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- Co-authors Med Uni Graz
- Beham-Schmid Christine
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- Abstract:
- Regarding diagnosis of polycythemia vera (PV), discussion persists about hemoglobin (Hb) and/or hematocrit (Hct) threshold values as surrogate markers for red cell mass (RCM) and the diagnostic impact of bone marrow (BM) morphology. We performed a retrospective study on 290 patients with PV (151 males, 139 females; median age 65 years) presenting with characteristic BM features (initial biopsies, centralized evaluation) and endogenous erythroid colony (EEC) formations. This cohort included (1) a group of 229 patients when following the 2008 versus 256 patients diagnosed according to the 2016 World Health Organization (WHO) guidelines, all presented with increased RCM; (2) masked PV patients with low Hb (n = 143)/Hct (n = 45) recruited from the 2008 WHO cohort; (3) a cohort of 17 PV patients with elevated diagnostic Hb/Hct levels but low RCM; and (4) nine PV patients with increased RCM, opposing low Hb/Hct values. All patients were treated according to current PV guidelines (phlebotomies 87%, hydroxyurea 79%, and acetylsalicylic acid 87%). Applying the 2016 WHO criteria significantly increased concordance between RCM and Hb values compared with the 2008 WHO criteria (90 vs. 43% in males and 83 vs. 64% in females). Further analysis of the WHO 2016 PV cohort revealed that increased RCM is associated with increased Hb/Hct (93.8/94.6%). Our study supports and extends the diagnostic impact of the 2016 revised WHO classification for PV by highlighting the importance of characteristic BM findings and implies that Hb/Hct threshold values may be used as surrogate markers for RCM measurements.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Biomarkers - analysis
- Cell Shape -
- Erythrocyte Volume - physiology
- Erythrocytes - pathology
- Female -
- Hematocrit - standards
- Hematologic Tests - standards
- Hemoglobins - analysis
- Humans -
- Male -
- Medical Oncology - standards
- Middle Aged -
- Polycythemia Vera - blood
- Polycythemia Vera - diagnosis
- Retrospective Studies -
- World Health Organization -
- Find related publications in this database (Keywords)
- Polycythemia vera
- Red cellmass
- Clinical criteria
- Bone marrow morphology
- Masked polycythemia vera
- WHO classification 2016