Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Odler, B; Ivancsó, I; Somogyi, V; Benke, K; Tamási, L; Gálffy, G; Szalay, B; Müller, V.
Vitamin D deficiency is associated with impaired disease control in asthma-COPD overlap syndrome patients.
Int J Chron Obstruct Pulmon Dis. 2015; 10(6): 2017-2025.
Doi: 10.2147/COPD.S91654
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- Odler Balazs
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- Abstract:
- The association between vitamin D and clinical parameters in obstructive lung diseases (OLDs), including COPD and bronchial asthma, was previously investigated. As asthma-COPD overlap syndrome (ACOS) is a new clinical entity, the prevalence of vitamin D levels in ACOS is unknown. Our aim was to assess the levels of circulating vitamin D (25-hydroxyvitamin D [25(OH)D]) in different OLDs, including ACOS patients, and its correlation with clinical parameters. A total of 106 men and women (control, n=21; asthma, n=44; COPD, n=21; and ACOS, n=20) were involved in the study. All patients underwent detailed clinical examinations; disease control and severity was assessed by disease-specific questionnaires (COPD assessment test, asthma control test, and modified Medical Research Council); furthermore, 25(OH)D levels were measured in all patients. The 25(OH)D level was significantly lower in ACOS and COPD groups compared to asthma group (16.86±1.79 ng/mL and 14.27±1.88 ng/mL vs 25.66±1.91 ng/mL). A positive correlation was found between 25(OH)D level and forced expiratory volume in 1 second (r=0.4433; P<0.0001), forced vital capacity (FVC) (r=0.3741; P=0.0004), forced expiratory flow between 25% and 75% of FVC (r=0.4179; P<0.0001), and peak expiratory flow (r=0.4846; P<0.0001) in OLD patient groups. Asthma control test total scores and the 25(OH)D level showed a positive correlation in the ACOS (r=0.4761; P=0.0339) but not in the asthma group. Higher COPD assessment test total scores correlated with decreased 25(OH)D in ACOS (r=-0.4446; P=0.0495); however, this was not observed in the COPD group. Vitamin D deficiency is present in ACOS patients and circulating 25(OH)D level may affect disease control and severity.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Asthma - physiopathology
- Case-Control Studies -
- Female -
- Forced Expiratory Volume - physiology
- Humans -
- Male -
- Middle Aged -
- Pulmonary Disease, Chronic Obstructive - physiopathology
- Quality of Life -
- Risk Factors -
- Surveys and Questionnaires -
- Vitamin D - analogs & derivatives
- Vitamin D - blood
- Vitamin D Deficiency - epidemiology
- Find related publications in this database (Keywords)
- ACOS
- obstructive lung disease
- CAT