Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fröhlich, E; Wahl, R.
The forgotten effects of thyrotropin-releasing hormone: Metabolic functions and medical applications.
Front Neuroendocrinol. 2019; 52(sup2):29-43
Doi: 10.1016/j.yfrne.2018.06.006
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- Führende Autor*innen der Med Uni Graz
- Fröhlich Eleonore
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- Abstract:
- Thyrotropin-releasing hormone (TRH) causes a variety of thyroidal and non-thyroidal effects, the best known being the feedback regulation of thyroid hormone levels. This was employed in the TRH stimulation test, which is currently little used. The role of TRH as a cancer biomarker is minor, but exaggerated responses to TSH and prolactin levels in breast cancer led to the hypothesis of a potential role for TRH in the pathogenesis of this disease. TRH is a rapidly degraded peptide with multiple targets, limiting its suitability as a biomarker and drug candidate. Although some studies reported efficacy in neural diseases (depression, spinal cord injury, amyotrophic lateral sclerosis, etc.), therapeutic use of TRH is presently restricted to spinocerebellar degenerative disease. Regulation of TRH production in the hypothalamus, patterns of expression of TRH and its receptor in the body, its role in energy metabolism and in prolactin secretion are addressed in this review. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (Keywords)
- Thyrotropin-releasing hormone
- Prolactin
- Thyroid disorders
- TRH stimulation assay
- Hypothalamic-pituitary axis