Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wolff, D; Greinix, H; Lee, SJ; Gooley, T; Paczesny, S; Pavletic, S; Hakim, F; Malard, F; Jagasia, M; Lawitschka, A; Hansen, JA; Pulanic, D; Holler, E; Dickinson, A; Weissinger, E; Edinger, M; Sarantopoulos, S; Schultz, KR.
Biomarkers in chronic graft-versus-host disease: quo vadis?
Bone Marrow Transplant. 2018; 53(7):832-837
Doi: 10.1038/s41409-018-0092-x
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Biomarkers are increasingly used for diagnosis and treatment of transplant-related complications including the first biomarker-driven interventional trials of acute graft-versus-host disease (GvHD). In contrast, the development of biomarkers of chronic GvHD (cGvHD) has lagged behind due to a broader variety of manifestations, overlap with acute GvHD, a greater variation in time to onset and maximum severity, and lack of sufficient patient numbers within prospective trials. An international workshop organized by a North-American and European consortium was held in Marseille in March 2017 with the goal to discuss strategies for future biomarker development to guide cGvHD therapy. As a result of this meeting, two areas were prioritized: the development of prognostic biomarkers for subsequent onset of moderate/severe cGvHD, and in parallel, the development of qualified clinical-grade assays for biomarker quantification. The most promising prognostic serum biomarkers are CXCL9, ST2, matrix metalloproteinase-3, osteopontin, CXCL10, CXCL11, and CD163. Urine-proteomics and cellular subsets (CD4+ T-cell subsets, NK cell subsets, and CD19+CD21low B cells) represent additional potential prognostic biomarkers of cGvHD. A joint effort is required to verify the results of numerous exploratory trials before any of the potential candidates is ready for validation and subsequent clinical application.
- Find related publications in this database (using NLM MeSH Indexing)
- Biomarkers - metabolism
- Chronic Disease -
- Female -
- Graft vs Host Disease - diagnosis
- Graft vs Host Disease - pathology
- Humans -
- Male -
- Prognosis -