Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mörkl, S; Lackner, S; Meinitzer, A; Gorkiewicz, G; Kashofer, K; Painold, A; Holl, A; Holasek, S.
[Pilot study: Gut microbiome and intestinal barrier in anorexia nervosa].
Fortschr Neurol Psychiatr. 2019; 87(1):39-45
Doi: 10.1055/s-0043-123826
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Leal Garcia Sabrina
- Co-Autor*innen der Med Uni Graz
- Gorkiewicz Gregor
- Holasek Sandra Johanna
- Holl Anna
- Kashofer Karl
- Lackner Sonja
- Meinitzer Andreas
- Painold Annamaria
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- Abstract:
- Recent research has shown changes of the intestinal flora in anorexia nervosa (AN) patients. Alpha diversity (AD) represents the number of different bacterial species in the gut. Reduced AD and a leaky gut (zonulin) lead to inflammation and changes in nutrient absorption. AD was calculated from stool samples of 18 AN patients and 20 normal weight controls (NC) after 16S ribosomal RNA sequencing. Furthermore, Zonulin as an indicator of gut barrier function and inflammation parameters were investigated. AN patients had significantly lower AD compared to NC (number of observed species p=0.042, Chao1 Diversity Index p=0.043). Zonulin was not significantly altered in AN patients compared to NC. There were no significant correlations of serum parameters and AD. Regardless of gut permeability, AN patients showed significantly decreased AD compared to NC. Decreased AD can have an additional negative impact on calorie intake in AN. These results contribute to a better understanding of the illness and the development of new therapeutic options. © Georg Thieme Verlag KG Stuttgart · New York.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Anorexia Nervosa - microbiology
- Anorexia Nervosa - physiopathology
- Gastrointestinal Microbiome -
- Humans -
- Inflammation - microbiology
- Inflammation - physiopathology
- Intestinal Mucosa - microbiology
- Intestinal Mucosa - physiopathology
- Permeability -
- Pilot Projects -
- Young Adult -
- Find related publications in this database (Keywords)
- anorexia nervosa
- microbiome
- alpha diversity
- zonulin
- gut barrier
- gut microbiome