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Denning, DW; Page, ID; Chakaya, J; Jabeen, K; Jude, CM; Cornet, M; Alastruey-Izquierdo, A; Bongomin, F; Bowyer, P; Chakrabarti, A; Gago, S; Guto, J; Hochhegger, B; Hoenigl, M; Irfan, M; Irurhe, N; Izumikawa, K; Kirenga, B; Manduku, V; Moazam, S; Oladele, RO; Richardson, MD; Tudela, JLR; Rozaliyani, A; Salzer, HJF; Sawyer, R; Simukulwa, NF; Skrahina, A; Sriruttan, C; Setianingrum, F; Wilopo, BAP; Cole, DC; Getahun, H.
Case Definition of Chronic Pulmonary Aspergillosis in Resource-Constrained Settings.
Emerg Infect Dis. 2018; 24(8):
Doi: 10.3201/eid2408.171312
[OPEN ACCESS]
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
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Hönigl Martin
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Salzer Helmut J. F.
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- Abstract:
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Chronic pulmonary aspergillosis (CPA) is a recognized complication of pulmonary tuberculosis (TB). In 2015, the World Health Organization reported 2.2 million new cases of nonbacteriologically confirmed pulmonary TB; some of these patients probably had undiagnosed CPA. In October 2016, the Global Action Fund for Fungal Infections convened an international expert panel to develop a case definition of CPA for resource-constrained settings. This panel defined CPA as illness for >3 months and all of the following: 1) weight loss, persistent cough, and/or hemoptysis; 2) chest images showing progressive cavitary infiltrates and/or a fungal ball and/or pericavitary fibrosis or infiltrates or pleural thickening; and 3) a positive Aspergillus IgG assay result or other evidence of Aspergillus infection. The proposed definition will facilitate advancements in research, practice, and policy in lower- and middle-income countries as well as in resource-constrained settings.
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Chronic Disease -
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Developing Countries -
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Humans -
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Practice Guidelines as Topic -
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Pulmonary Aspergillosis - diagnosis
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Pulmonary Aspergillosis - microbiology
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Pulmonary Aspergillosis - pathology
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Socioeconomic Factors -