Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Storga, D; Vrecko, K; Birkmayer, JG; Reibnegger, G.
Monoaminergic neurotransmitters, their precursors and metabolites in brains of Alzheimer patients.
Neurosci Lett. 1996; 203(1):29-32 Doi: 10.1016%2F0304-3940%2895%2912256-7
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Co-Autor*innen der Med Uni Graz: Reibnegger Gilbert; Vrecko Karoline
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Abstract:: The catecholamines dopamine (DA), noradrenaline (NA) and adrenaline (A), their aminoacid precursors tyrosine (Tyr), L-3,4-dihydroxyphenylalanine (L-DOPA), two of their metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and 4-hydroxy-3-methoxy phenyl glycol (MHPG), serotonin (5-HT) and its precursor tryptophan (Trp), were measured by high pressure liquid chromatography (HPLC) with electrochemical detection in seven regions (globus pallidus, putamen, nucleus amygdalae, nucleus caudatus, substantia nigra, gyrus cinguli and raphe) of postmortem brains from eight histologically verified cases with Alzheimer's disease (AD) and six histologically normal controls. Concentrations of L-DOPA, DA, DOPAC, NA and 5-HT were significantly reduced, while Tyr and MHPG concentrations were significantly increased in AD versus control patients. The concentrations of Trp and A in AD patients were not significantly different from controls. Furthermore, for most brain regions examined, significant negative correlations between Tyr and DA as well as between NA and MHPG levels were found. These data confirm and extend findings of monoaminergic systems disturbances in AD, emphasize the significance of dopaminergic deficit for AD and suggest that in pharmacotherapy of AD, attempts to restore deficits of the transmitter systems should be directed to the monoaminergic, in particular the dopaminergic system.
Find related publications in this database (using NLM MeSH Indexing): 3,4-Dihydroxyphenylacetic Acid - metabolism; Aged - metabolism; Alzheimer Disease - metabolism; Brain - metabolism; Dopamine - metabolism; Epinephrine - metabolism; Humans - metabolism; Middle Aged - metabolism; Neurotransmitter Agents - metabolism; Serotonin - metabolism; Tissue Distribution - metabolism