Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Volkenandt, M; Soyer, HP; Cerroni, L; Koch, OM; Atzpodien, J; Kerl, H.
Molecular detection of clone-specific DNA in hypopigmented lesions of a patient with early evolving mycosis fungoides.
BRIT J DERMATOL 1993 128: 423-428.
Doi: 10.1111/j.1365-2133.1993.tb00203.x
(- Case Report)
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Cerroni Lorenzo
- Kerl Helmut
- Soyer Hans Peter
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- Abstract:
- A specific molecular probe for the malignant lymphoid clone of lesions of a patient with mycosis fungoides was developed. As a clone-specific marker the junctional region of rearranged T-cell-receptor-gamma (TCR-gamma) genes was used. An oligonucleotide primer complementary to these sequences was designed. Using this primer and polymerase chain-reaction technology, early hypopigmented lesions of the patient, which were previously unclassifiable by conventional microscopy, were analysed. The study demonstrates, on the molecular level, that these hypopigmented lesions contain tumour clone-specific DNA and may represent early manifestations of mycosis fungoides.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Base Sequence -
- DNA - analysis
- DNA Probes - analysis
- Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor - analysis
- Humans - analysis
- Male - analysis
- Molecular Sequence Data - analysis
- Mycosis Fungoides - genetics
- Polymerase Chain Reaction - genetics
- Skin - pathology