Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Trimmel, H; Helbok, R; Staudinger, T; Jaksch, W; Messerer, B; Schöchl, H; Likar, R.
S(+)-ketamine : Current trends in emergency and intensive care medicine.
Wien Klin Wochenschr. 2018; 130(9-10):356-366
Doi: 10.1007/s00508-017-1299-3
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- Co-Autor*innen der Med Uni Graz
- Likar Rudolf
- Messerer Brigitte
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- Abstract:
- S(+)-ketamine, the pure dextrorotatory enantiomer of ketamine has been available for clinical use in analgesia and anesthesia for more than 25 years. The main effects are mediated by non-competitive inhibition of the N-methyl-D-aspartate (NMDA) receptor but S(+)-ketamine also interacts with opioid receptors, monoamine receptors, adenosine receptors and other purinergic receptors. Effects on α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, metabotropic glutamate receptors (mGluR) and L‑type calcium chanels have also been described. S(+)-ketamine stimulates the sympathetic nerve system, making it an ideal drug for analgosedation or induction of anesthesia in instable patients. In addition, the neuroprotective properties, bronchodilatory, antihyperalgesic or antiepileptic effects provide interesting therapeutic options. In this article we discuss the numerous effects of S(+)-ketamine under pharmacological and clinical aspects especially for typical indications in emergency medicine as well as intensive care.
- Find related publications in this database (using NLM MeSH Indexing)
- Analgesics - administration & dosage
- Anesthetics, Dissociative - administration & dosage
- Critical Care - administration & dosage
- Humans - administration & dosage
- Ketamine - administration & dosage, pharmacology
- Receptors, AMPA - metabolism
- Receptors, N-Methyl-D-Aspartate - metabolism
- Find related publications in this database (Keywords)
- Ketamine
- Analgesia
- Neuroprotection
- Emergency medicine
- Critical care