Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Regauer, S.
Immune dysregulation in lichen sclerosus.
Eur J Cell Biol. 2005; 84(2-3):273-277
Doi: 10.1016/j.ejcb.2004.12.003
Web of Science
PubMed
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FullText_MUG
- Leading authors Med Uni Graz
- Regauer Sigrid
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- Abstract:
- Lichen sclerosus (LS) is a chronic localized lymphocyte-mediated dermatosis of genital skin with a presumed autoimmune origin. LS is characterized by localized dense lymphocytic tissue infiltrates, vasculitic processes and extensive tissue destruction. The lymphocytic infiltrate of LS biopsies contains between 1.4% and 21% of T-cells with monoclonally rearranged T-cell receptor gamma-chain gene, and the immunophenotype is dominated by B-cells, CD4-positive T-cells and antigen-presenting dendritic cells. Antigen-driven selection of T-cells and restricted T-cell receptor usage reflects prolonged exposure of the host immune system to a local (putative LS-associated) antigen. It is presently unclear at which time point in the evolution of LS the T-cell clones emerge. All investigators of LS agree on the non-neoplastic nature of the infiltrate. However, a small percentage of LS patients show serological (systemic) evidence of T-cell immune deficiencies. The lack of long-term follow up of patients with known monoclonally rearranged T-cell receptor gamma-chain gene in their LS biopsies, however, defers a final judgement on the clinical significance of our observations.
- Find related publications in this database (using NLM MeSH Indexing)
- Antibody Formation - immunology
- Humans - immunology
- Immunity, Cellular - immunology
- Lichen Sclerosus et Atrophicus - immunology
- T-Lymphocytes - immunology
- Vasculitis - immunology
- Find related publications in this database (Keywords)
- lichen sclerosus
- T-cell receptor gamma chain
- T cell clones