Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bagga, D; Reichert, JL; Koschutnig, K; Aigner, CS; Holzer, P; Koskinen, K; Moissl-Eichinger, C; Schöpf, V.
Probiotics drive gut microbiome triggering emotional brain signatures.
Gut Microbes. 2018; 9(6):486-496
Doi: 10.1080/19490976.2018.1460015
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Holzer Peter
- Koschutnig Karl
- Koskinen Mora Kaisa
- Moissl-Eichinger Christine
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- Abstract:
- Experimental manipulation of the gut microbiome was found to modify emotional and cognitive behavior, neurotransmitter expression and brain function in rodents, but corresponding human data remain scarce. The present double-blind, placebo-controlled randomised study aimed at investigating the effects of 4 weeks' probiotic administration on behavior, brain function and gut microbial composition in healthy volunteers. Forty-five healthy participants divided equally into three groups (probiotic, placebo and no intervention) underwent functional MRI (emotional decision-making and emotional recognition memory tasks). In addition, stool samples were collected to investigate the gut microbial composition. Probiotic administration for 4 weeks was associated with changes in brain activation patterns in response to emotional memory and emotional decision-making tasks, which were also accompanied by subtle shifts in gut microbiome profile. Microbiome composition mirrored self-reported behavioral measures and memory performance. This is the first study reporting a distinct influence of probiotic administration at behavioral, neural, and microbiome levels at the same time in healthy volunteers. The findings provide a basis for future investigations into the role of the gut microbiota and potential therapeutic application of probiotics.
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