Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tripolt, NJ; Aberer, F; Riedl, R; Url, J; Dimsity, G; Meinitzer, A; Stojakovic, T; Aziz, F; Hödl, R; Brachtl, G; Strunk, D; Brodmann, M; Hafner, F; Sourij, H.
Effects of linagliptin on endothelial function and postprandial lipids in coronary artery disease patients with early diabetes: a randomized, placebo-controlled, double-blind trial.
Cardiovasc Diabetol. 2018; 17(1):71-71
Doi: 10.1186/s12933-018-0716-x
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- Führende Autor*innen der Med Uni Graz
- Sourij Harald
- Tripolt Norbert
- Co-Autor*innen der Med Uni Graz
- Aberer Felix
- Brodmann Marianne
- Dimsity Gudrun
- Hafner Franz
- Hödl Ronald
- Meinitzer Andreas
- Riedl Regina
- Stojakovic Tatjana
- Strunk Dirk
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- Abstract:
- Early glucose lowering intervention in subjects with type 2 diabetes mellitus was demonstrated to be beneficial in terms of micro- and macrovascular risk reduction. However, most of currently ongoing cardiovascular outcome trials are performed in subjects with manifest atherosclerosis and long-standing diabetes. Therefore, the aim of this study is to investigate the effects of the dipeptidylpeptidase-4 inhibitor linagliptin in subjects with coronary artery disease (CAD) but early type 2 diabetes mellitus (T2DM) on a set of cardiovascular surrogate measurements. In this randomized, placebo-controlled, double-blind, single-center study, we included subjects with early diabetes (postchallenge diabetes (2 h glucose > 200 mg/dl) or T2DM treated with diet only or on a stable dose of metformin monotherapy and an HbA1c < 75 mmol/mol) and established CAD. Participants were randomized to receive either linagliptin (5 mg) once daily orally or placebo for 12 weeks. The primary outcome was the change in flow mediated dilatation (FMD). The secondary objective was to investigate the effect of linagliptin treatment on arginine bioavailability ratios [Global arginine bioavailability ratio (GABR) and arginine to ornithine ratio (AOR)]. Arginine, ornithine and citrulline were measured in serum samples with a conventional usual amino acid analysis technique, involving separation of amino acids by ion exchange chromatography followed by postcolumn continuous reaction with ninhydrin. GABR was calculated by L-arginine divided by the sum of (L-ornithine plus L-citrulline). The AOR was calculated by dividing L-arginine by L-ornithine levels. Group comparisons were calculated by using a two-sample t-test with Satterthwaite adjustment for unequal variances. We investigated 43 patients (21% female) with a mean age of 63.3 ± 8.2 years. FMD at baseline was 3.5 ± 3.1% in the linagliptin group vs. 4.0 ± 2.9% in the placebo group. The change in mean FMD in the linagliptin group was not significantly different compared to the change in the placebo group (0.43 ± 4.84% vs. - 0.45 ± 3.01%; p = 0.486). No significant improvements were seen in the arginine bioavailability ratios (GABR; p = 0.608 and AOR; p = 0.549). Linagliptin treatment in subjects with CAD and early T2DM did not improve endothelial function or the arginine bioavailability ratios. Trial registration ClinicalTrials.gov, NCT02350478 ( https://clinicaltrials.gov/ct2/show/NCT02350478 ).
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Arginine - blood
- Arginine -
- Biomarkers - blood
- Blood Glucose - drug effects
- Blood Glucose - metabolism
- Citrulline - blood
- Coronary Artery Disease - blood
- Coronary Artery Disease - diagnosis
- Coronary Artery Disease - drug therapy
- Coronary Artery Disease - physiopathology
- Diabetes Mellitus, Type 2 - blood
- Diabetes Mellitus, Type 2 - diagnosis
- Diabetes Mellitus, Type 2 - drug therapy
- Diabetes Mellitus, Type 2 - physiopathology
- Dipeptidyl-Peptidase IV Inhibitors - adverse effects
- Dipeptidyl-Peptidase IV Inhibitors - therapeutic use
- Double-Blind Method -
- Endothelium, Vascular - drug effects
- Endothelium, Vascular - metabolism
- Endothelium, Vascular - physiopathology
- Female -
- Glycated Hemoglobin A - metabolism
- Humans -
- Linagliptin - adverse effects
- Linagliptin - therapeutic use
- Lipids - blood
- Male -
- Middle Aged -
- Ornithine - blood
- Postprandial Period -
- Prospective Studies -
- Time Factors -
- Treatment Outcome -
- Vasodilation - drug effects
- Find related publications in this database (Keywords)
- Linagliptin
- Flow mediated dilatation
- RCT
- DPP-4 inhibitor
- Type 2 diabetes
- Coronary artery disease
- Endothelial function