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Wiesner, T; Streubel, B; Huber, D; Kerl, H; Chott, A; Cerroni, L.
Genetic aberrations in primary cutaneous large B-cell lymphoma: a fluorescence in situ hybridization study of 25 cases.
AMER J SURG PATHOL. 2005; 29(5): 666-673.
Doi: 10.1097%2F01.pas.0000155163.40668.e7
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- Leading authors Med Uni Graz
- Cerroni Lorenzo
- Wiesner Thomas
- Co-authors Med Uni Graz
- Kerl Helmut
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- Abstract:
- In contrast to nodal large B-cell lymphomas, recurrent chromosomal aberrations have been studied only in a small number of cases of primary cutaneous diffuse large B-cell lymphoma (PCDLBCL). We investigated 25 PCDLBCLs (classified according to the WHO-EORTC classification into PCDLBCL, leg-type, 8; and PCDLBCL, other, 17), using an interphase fluorescence in situ hybridization technique. All cases were analyzed for chromosomal aberrations commonly observed in nodal large B-cell lymphomas, including structural aberrations of the genes BCL2, BCL6, and c-MYC, and numerical aberrations of the chromosomes/genes 3, 7, 8, 11, 12, 13, 17, 18q, RB1, and p53. We observed genetic aberrations in 19 (76%) of 25 patients. The most frequent numerical aberrations were gains of chromosome 12 (7 of 25, 28%), 7 (5 of 25, 20%), 3 (5 of 25, 20%), 18q (3 of 25, 12%), 11 (3 of 25, 12%), X (3 of 25, 12%), and losses of chromosome/gene 17/p53 (3 of 25, 12%). BCL2, c-MYC, and BCL6 were rearranged with the IGH gene in 4 (16%), 1 (4%), and none (0%) of 25 cases, respectively. Most aberrations were homogeneously distributed among cases of PCDLBCL, leg-type and of PCDLBCL, other, cases located on the leg or at other body sites, cases with round and cleaved cell morphology, and Bcl-2+ and Bcl-2- cases. These results suggest that PCDLBCLs show similar chromosomal aberrations irrespective of classification, anatomic site, cell morphology, and Bcl-2 expression, and that many similarities between primary cutaneous and nodal diffuse large B-cell lymphomas can be observed.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Chromosome Aberrations -
- DNA, Neoplasm - analysis
- Female - analysis
- Humans - analysis
- Immunohistochemistry - analysis
- In Situ Hybridization, Fluorescence - analysis
- Leg - pathology
- Lymphoma, B-Cell - chemistry
- Lymphoma, Large-Cell, Diffuse - chemistry
- Male - chemistry
- Middle Aged - chemistry
- Skin Neoplasms - chemistry
- Tumor Markers, Biological - analysis
- Find related publications in this database (Keywords)
- B-cell lymphoma
- chromosome aberrations
- cutaneous large B-cell lymphoma of the leg
- in situ hybridization
- skin neoplasms