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SHR Neuro Cancer Cardio Lipid Metab Microb
Kutschera, J; Tomaselli, J; Maurer, U; Mueller, W; Urlesberger, B.
Minor neurological dysfunction, cognitive development, and somatic development at the age of 3 to 7 years after dexamethasone treatment in very-low birth-weight infants.
Early Hum Dev. 2005; 81(3):281-287
Doi: 10.1016/j.earlhumdev.2004.07.004
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- Co-authors Med Uni Graz
- Maurer-Fellbaum Ute
- Müller Wilhelm
- Urlesberger Berndt
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- Abstract:
- The objective of this study was to assess minor neurological dysfunction, cognitive development, and somatic development after dexamethasone therapy in very-low-birthweight infants. Thirty-three children after dexamethasone treatment were matched to 33 children without dexamethasone treatment. Data were assessed at the age of 3-7 years. Dexamethasone was started between the 7th and the 28th day of life over 7 days with a total dose of 2.35 mg/kg/day. Exclusion criteria were asphyxia, malformations, major surgical interventions, small for gestational age, intraventricular haemorrhage grades III and IV, periventricular leukomalacia, and severe psychomotor retardation. Each child was examined by a neuropediatrician for minor neurological dysfunctions and tested by a psychologist for cognitive development with a Kaufman Assessment Battery for Children and a Draw-a-Man Test. There were no differences in demographic data, growth, and socio-economic status between the two groups. Fine motor skills and gross motor function were significantly better in the control group (p<0.01). In the Draw-a-Man Test, the control group showed better results (p<0.001). There were no differences in development of speech, social development, and the Kaufman Assessment Battery for Children. After dexamethasone treatment, children showed a higher rate of minor neurological dysfunctions. Neurological development was affected even without neurological diagnosis. Further long-term follow-up studies will be necessary to fully evaluate the impact of dexamethasone on neurological and cognitive development.
- Find related publications in this database (using NLM MeSH Indexing)
- Child -
- Child, Preschool -
- Cognition - drug effects
- Dexamethasone - adverse effects
- Female - adverse effects
- Glucocorticoids - adverse effects
- Humans - adverse effects
- Infant, Newborn - adverse effects
- Infant, Very Low Birth Weight - physiology
- Male - physiology
- Nervous System Diseases - chemically induced
- Retrospective Studies - chemically induced
- Find related publications in this database (Keywords)
- dexamethasone
- long-term outcome
- cognitive development
- neurological development
- minor neurological dysfunction