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SHR Neuro Cancer Cardio Lipid Metab Microb
El Shabrawi-Caelen, L; Kerl, H; Cerroni, L.
Lymphomatoid papulosis: reappraisal of clinicopathologic presentation and classification into subtypes A, B, and C.
ARCH DERMATOL. 2004; 140(4): 441-447.
Doi: 10.1001/archderm.140.4.441
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- Leading authors Med Uni Graz
- Cerroni Lorenzo
- El-Shabrawi-Caelen Laila
- Co-authors Med Uni Graz
- Kerl Helmut
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- Abstract:
- OBJECTIVES: To analyze clinicopathologic features of lymphomatoid papulosis and delineate the characteristics of histopathologic variants (types A, B, and C). DESIGN: Retrospective nonrandomized study. SETTING: University-based dermatologic referral center. PATIENTS: Eighty-five patients with lymphomatoid papulosis. Clinical data and 1 or more biopsy specimens were available for review in all cases. When possible, immunophenotypic and molecular analyses were carried out. RESULTS: Of these patients, 78 presented only 1 histopathologic subtype of lymphomatoid papulosis (64 had type A, 3 had type B, and 11 had type C). The last 7 patients presented more than 1 subtype (1 had A and B, 5 had A and C, and 1 had A, B, and C). Two patients had regional lymphomatoid papulosis, an unusual clinical presentation characterized by groups of lesions localized to 1 anatomic region. We observed, we believe for the first time, that some histopathologic patterns, ie, follicular mucinosis (n = 1), syringotropic infiltrates (n = 1), epidermal vesicle formation (n = 2), and syringosquamous metaplasia (n = 1), were associated with lymphomatoid papulosis. A distribution along hair follicles, or follicular lymphomatoid papulosis, was observed in 5 biopsy specimens. A bandlike rather than a wedge distribution of the infiltrate was seen in 5 specimens from patients with lymphomatoid papulosis type A. Of 8 patients who had associated lymphoid malignancies, 4 had Hodgkin disease and 4 had mycosis fungoides. CONCLUSIONS: Lymphomatoid papulosis is a cutaneous disorder with multiple clinicopathologic features. Differentiating between mycosis fungoides and anaplastic large cell lymphoma may be very difficult and sometimes impossible. In the spectrum of CD30(+) cutaneous lymphoproliferative disorders, boundaries between these 2 entities are not clear-cut.
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- Immunohistochemistry - pathology
- Incidence - pathology
- Lymphomatoid Papulosis - classification
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