Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schippinger, W; Jagoditsch, M; Sorré, C; Gnant, M; Steger, G; Hausmaninger, H; Mlineritsch, B; Schaberl-Moser, R; Mischinger, HJ; Hofbauer, F; Holzberger, P; Mittlböck, M; Jakesz, R; Austrian Breast and Colorectal Cancer Study Group.
A prospective randomised trial to study the role of levamisole and interferon alfa in an adjuvant therapy with 5-FU for stage III colon cancer.
BRIT J CANCER. 2005; 92(9): 1655-1662.
Doi: 10.1038/sj.bjc.6602555
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- Führende Autor*innen der Med Uni Graz
- Schippinger Walter
- Co-Autor*innen der Med Uni Graz
- Mischinger Hans-Jörg
- Schaberl-Moser Renate
- Study Group Mitglieder der Med Uni Graz:
- Kronberger Leo
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- Abstract:
- The purpose of this trial was to examine the efficacy of the addition of levamisole (LEV) or interferon alfa (IFN) to an adjuvant chemotherapy with 5-fluorouracil (5-FU) in patients with stage III colon cancer. According to a 2 x 2 factorial study design, 598 patients were randomly assigned to one of four adjuvant treatment arms. Patients in arm one received 5-FU weekly for 1 year, patients in arm two 5-FU plus LEV, in arm three 5-FU plus IFN and patients in arm four 5-FU, LEV and IFN. The relative risk of relapse and the relative risk of death were significantly higher for patients treated with LEV compared with those without LEV treatment (HR 1.452, 95% CI 1.135-1.856, P=0.0028; HR 1.506, 95% CI 1.150-1.973, P=0.0027, respectively). No significant impact on survival was observed for therapy with IFN in the univariate analysis. The addition of LEV to adjuvant 5-FU significantly worsened the prognosis of patients with stage III colon cancer. Interferon alfa had no significant influence on survival when combined with adjuvant 5-FU, but increased the toxicity of therapy substantially.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Colonic Neoplasms - drug therapy Colonic Neoplasms - surgery
- Combined Modality Therapy -
- Disease-Free Survival -
- Drug Administration Schedule -
- Female -
- Fluorouracil - administration and dosage
- Humans -
- Interferon-alpha - administration and dosage Interferon-alpha - adverse effects
- Leucovorin - administration and dosage
- Levamisole - administration and dosage
- Male -
- Middle Aged -
- Neoplasm Recurrence, Local -
- Prognosis -
- Survival Analysis -
- Find related publications in this database (Keywords)
- colon cancer
- adjuvant therapy
- levamisole
- interferon