Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sauerschnig, M; Stolberg-Stolberg, J; Schulze, A; Salzmann, GM; Perka, C; Dynybil, CJ.
Diverse expression of selected cytokines and proteinases in synovial fluid obtained from osteoarthritic and healthy human knee joints.
Eur J Med Res. 2014; 19(8): 65-65.
Doi: 10.1186/s40001-014-0065-5
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- Führende Autor*innen der Med Uni Graz
- Sauerschnig Martin
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- Abstract:
- Osteoarthritis (OA) is defined by signs and symptoms of inflammation within the affected joint. The aim of this study is to determine the mRNA expression levels of selected cytokines and matrix-metalloproteinases of cells found in synovial fluid (SF) obtained from osteoarthritic knee joints compared to healthy controls. SF was obtained from 40 patients undergoing total knee arthroplasty due to evident OA and from 10 healthy controls. Expression of TNF-α, IL-1β, MMP-1 and MMP-3 was assayed among both groups by performing qPCR. Patients were configured concerning age, gender and BMI. IL-1β, MMP-1 and MMP-3 showed significantly higher expression among the OA group compared to control (P < 0.001). Strong correlation appeared between expression of MMP-1 and MMP-3 among OA patients (r = 0.856); no correlation was found between age, gender or BMI and cytokine/proteinase expression. Expression of IL-1β, MMP-1 and MMP-3 within SF was elevated in OA-patients. Consequently, cells within SF expressing cytokines and proteinases may play a relevant role in the progression of joint destruction. Considering the fact that SF in an OA joint comprises abnormal amounts of detrimental bioactive proteins, temporary clearance, dilution or suppression/modulation by means of lavage or disease-modifying medication may be promising to constitute interim relief or even postpone disease progression due to decreased inflammatory and/or degrading activity within the articular environment.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Cytokines - metabolism
- Female -
- Humans -
- Knee Joint - metabolism
- Male -
- Matrix Metalloproteinase 1 - metabolism
- Matrix Metalloproteinase 3 - metabolism
- Middle Aged -
- Osteoarthritis - metabolism
- Synovial Fluid - metabolism
- Find related publications in this database (Keywords)
- Cytokines
- Proteinases
- Osteoarthritis
- Cartilage
- Synovial fluid
- Biomarkers