Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Benesch, M; Sovinz, P; Lackner, H; Schwinger, W; Dornbusch, HJ; Urban, C.
Five-month marrow aplasia in a child with refractory acute myeloid leukemia: successful management with continuous granulocyte support and reduced-intensity conditioning followed by matched unrelated bone marrow transplantation.
J PEDIAT HEMATOL ONCOL. 2005; 27(4): 236-238.
Doi: 10.1097/01.mph.0000161639.78215.b1
(- Case Report)
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Benesch Martin
- Co-Autor*innen der Med Uni Graz
- Dornbusch Hans Jürgen
- Lackner Herwig
- Ritter-Sovinz Petra
- Schwinger Wolfgang
- Urban Ernst-Christian
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- Abstract:
- A 10-year-old girl diagnosed with acute myeloid leukemia FAB M4 failed to achieve remission following several courses of induction chemotherapy. From the first course of chemotherapy the patient had continuous marrow aplasia, managed by a total of 57 granulocyte transfusions. After reinduction and reduced-intensity conditioning including fludarabine, Campath-1H, and melphalan, the patient received unmanipulated marrow from an HLA-matched unrelated donor. Leukocyte and platelet engraftment was observed on day +18 and +50, respectively. Graft-versus-host disease did not occur. The patient is alive and well in complete remission 18 months after transplantation with complete donor chimerism.
- Find related publications in this database (using NLM MeSH Indexing)
- Anemia, Aplastic - etiology
- Antibodies, Monoclonal - administration and dosage
- Antibodies, Neoplasm - administration and dosage
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Bone Marrow Transplantation - therapeutic use
- Child - therapeutic use
- Female - therapeutic use
- Graft vs Host Disease - prevention and control
- Granulocytes - pathology
- Humans - pathology
- Leukemia, Myelomonocytic, Acute - microbiology
- Melphalan - administration and dosage
- Neoplasm Recurrence, Local - microbiology
- Remission Induction - microbiology
- Transplantation Chimera - microbiology
- Transplantation Conditioning - microbiology
- Transplantation, Homologous - microbiology
- Vidarabine - administration and dosage
- Find related publications in this database (Keywords)
- children
- refractory acute myeloid leukemia
- reduced-intensity conditioning
- marrow aplasia
- stem cell transplantation