Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mayer-Pickel, K; Stern, C; Eberhard, K; Lang, U; Obermayer-Pietsch, B; Cervar-Zivkovic, M.
Angiogenic factors in pregnancies of women with antiphospholipid syndrome and systemic lupus erythematosus.
J Reprod Immunol. 2018; 127(4):19-23
Doi: 10.1016/j.jri.2018.04.002
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Mayer-Pickel Karoline Ilse
- Co-Autor*innen der Med Uni Graz
- Cervar-Zivkovic Mila
- Eberhard Katharina
- Lang Uwe
- Obermayer-Pietsch Barbara
- Stern Christina
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- Abstract:
- An imbalance of angiogenic placental factors such as endoglin, soluble fms-like tyrosine kinase 1(sFlt-1) and placental growth factor (PlGF) has been implicated in the pathophysiology of preeclampsia. This study aimed to evaluate serum levels of sFlt-1, PlGF and endoglin in women with primary and secondary antiphospholipid Syndrome (APS) and systemic lupus erythematosus (SLE) longitudinally through pregnancy. Serum levels of sFlt-1, PlGF and endoglin were measured prospectively at 4-week intervals (from gestational weeks 12-36) in 17 women with primary APS (PAPS), 18 women with secondary APS (SAPS), and 23 women with SLE. 6/17 (35%) of women with PAPS, 3/18 (17%) of women with SAPS, and 2/23 (9%) of women with SLE developed early-onset preeclampsia. Women who developed preeclampsia had significantly higher mean sFlt-1 and endoglin levels, higher sFlt-1/PlGF ratios, and lower mean PlGF-levels than women who did not. These changes became statistically significant at 12 weeks for sFlt-1, PlGF and endoglin. Endoglin, sFlt-1 and PlGF are potential early screening parameters for the development of preeclampsia in pregnant women with autoimmune diseases like APS and SLE. Copyright © 2018 Elsevier B.V. All rights reserved.
- Find related publications in this database (Keywords)
- Antiphospholipid syndrome
- Systemic lupus erythematosus
- Pregnancy
- Preeclampsia
- sFlt-1/PIGF-ratio