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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Donnerer, J; Liebmann, I.
Effect of CB1 Ligands on Neurogenic and Myogenic Contractile Responses in the Guinea-Pig Ileum.
Pharmacology. 2018; 101(5-6): 330-336.
Doi: 10.1159/000488682
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Donnerer Josef
- Co-authors Med Uni Graz
- Liebmann Ingrid
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- Abstract:
- This study aimed at investigating whether the synthetic cannabinoid receptor agonist (+)-WIN 55212-2 has neurogenic and myogenic relaxant effects on the longitudinal muscle-myenteric plexus (LMMP) strip of the guinea-pig ileum. (+)-WIN 55212-2, 1-1,000 nmol/L, concentration-dependently inhibited both the electrical stimulation-induced cholinergic twitch responses as well as the myogenic smooth muscle contractions in the LMMP preparation. SR-141716A (rimonabant) 1-1,000 nmol/L, the cannabinoid CB1 receptor antagonist, being without effect on its own, antagonized the (+)-WIN 55212-2-induced effects. The allyl isothiocyanate (mustard oil, 100 µmol/L) induced a relaxant effect in the guinea-pig ileum, which can be regarded as neurogenic and myogenic, was augmented by (+)-WIN 55212-2, and inhibited by SR-141716A. (+)-WIN 55212-2 only moderately modified the 60 mmol/L KCl-evoked contractions. These results provide functional evidence that the CB1 agonist (+)-WIN 55212-2-induced inhibitory effects in the guinea-pig ileum are exerted both at the neuronal as well as at the intestinal smooth muscle cell level. © 2018 S. Karger AG, Basel.
- Find related publications in this database (Keywords)
- Intestinal smooth muscle
- SR-141716A
- WIN 55212-2
- Allyl isothiocyanate
- Neurogenic and myogenic spasmolytic