Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Leithner, A; Weinhaeusel, A; Zeitlhofer, P; Koch, H; Radl, R; Windhager, R; Beham, A; Haas, OA.
Evidence of a polyclonal nature of myositis ossificans.
Virchows Arch. 2005; 446(4):438-441
Doi: 10.1007/s00428-004-1169-z
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Leithner Andreas
- Co-Autor*innen der Med Uni Graz
- Beham Alfred
- Koch Horst
- Radl Roman
- Windhager Reinhard
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- Abstract:
- Myositis ossificans is a localized, self-limiting, reparative lesion that is composed of reactive hypercellular fibrous tissue and bone. Although it is clearly a benign lesion, its clinical, radiological, and histological appearance may sometimes mimic a malignant tumor. Whether myositis ossificans represents a monoclonal or polyclonal hyperplastic proliferation is not yet known. To address this question, we therefore extracted DNA from the respective paraffin-embedded tumor tissues of nine women with a median age of 50 years at diagnosis (range: 20-84 years) and studied the X inactivation pattern by means of methylation-sensitive polymerase chain reaction and primers that target the polymorphic CGG trinucleotide repeat of the FMR1 gene. The fact that we did not detect any skewing of the X inactivation pattern in the five successfully analyzed cases corroborates the notion that myositis ossificans results from a polyclonal proliferation and confirms that it is a reactive, reparative process. Analysis of the X inactivation pattern may, thus, supplement the differential diagnostic work-up of cases with an uncertain histology, at least in the informative proportion of female patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Cell Proliferation -
- Clone Cells - pathology
- DNA Methylation - pathology
- Diagnosis, Differential - pathology
- Dosage Compensation, Genetic - pathology
- Female - pathology
- Humans - pathology
- Middle Aged - pathology
- Myositis Ossificans - genetics
- Sarcoma - diagnosis
- Soft Tissue Neoplasms - diagnosis
- Find related publications in this database (Keywords)
- myositis ossificans
- DNA methylation
- X inactivation
- polymerase chain reaction
- FMR1