Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zulus, B; Grünbacher, G; Kleber, ME; März, W; Renner, W.
The UGT1A1*28 gene variant predicts long-term mortality in patients undergoing coronary angiography.
Clin Chem Lab Med. 2018; 56(4):560-564
Doi: 10.1515/cclm-2017-0692
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- Führende Autor*innen der Med Uni Graz
- Renner Wilfried
- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- Uridine diphosphate glycosyltransferases 1A1 (UGT1A1) plays an essential role in detoxification and excretion of several endogenous and exogenous compounds. A functional polymorphism in the promoter of the UGT1A1 gene (TA repeat insertion, UGT1A1*28, rs3064744) has been associated with reduced UGT1A1 enzyme activity. The purpose of the present study was to investigate the role of UGT1A1 genotypes in mortality. UGT1A1 genotypes as well as baseline plasma bilirubin levels were analyzed in participants of the Ludwigshafen Risk and Cardiovascular Health study (n=3316). UGT1A1*28 genotypes were determined on an ABI PRISM 3730 genetic analyzer. As expected, UGT1A1 genotypes were associated with baseline bilirubin levels (*1/*1 genotype: 9.1±4.6 µmol/L; *1/*28 genotype: 10.8±5.3; *28/*28: 16.9±9.2; p<0.001). During a median follow-up of 10.4 years, 995 subjects (30.0%) died. In a multivariate regression analysis adjusting for age, sex, smoking, type 2 diabetes, dyslipidemia, alanine aminotransferase (ALT) levels and bilirubin levels, the UGT1A1*28 variant predicted lower overall mortality (hazard ratio [HR], 0.86; 95% confidence interval [CI], 0.78-0.95; p=0.003). Contrary to expected, higher baseline bilirubin levels predicted increased mortality (HR, 1.014; 95% CI, 1.002-1.025; p=0.019). The UGT1A1*28 gene variant is associated with lower mortality rates. The protective effect of the UGT1A1*28 variant likely includes mechanism other than bilirubin metabolism.
- Find related publications in this database (using NLM MeSH Indexing)
- Bilirubin - blood
- Bilirubin - genetics
- Cohort Studies -
- Coronary Angiography -
- Coronary Artery Disease - genetics
- Coronary Artery Disease - mortality
- Female -
- Genetic Variation - genetics
- Genotype -
- Glucuronosyltransferase - genetics
- Glucuronosyltransferase - metabolism
- Humans -
- Male -
- Middle Aged -
- Multivariate Analysis -
- Polymorphism, Genetic - genetics
- Predictive Value of Tests -
- Time Factors -
- Find related publications in this database (Keywords)
- mortality
- polymorphism
- UGT1A1