Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Nagl, UO; Erdel, M; Bergmann, F; Oehl, B; Scandella, E; Musante, L; Galietta, LJ; Gschwentner, M; Fürst, J; Schmarda, A; Hofer, S; Utermann, G; Deetjen, P; Paulmichl, M.
Characterization of the human gene coding for the swelling-dependent chloride channel ICln at position 11q13.5-14.1 (CLNS1A) and further characterization of the chromosome 6 (CLNS1B) localization.
Gene. 1998; 209(1-2):59-63
Doi: 10.1016/S0378-1119(98)00002-X
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- von Lewinski Friederike
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- Abstract:
- Expression cloning revealed a chloride channel (ICln) that we found to be fundamental for the regulatory volume decrease in a variety of cells. The chromosomal localization of the human ICln-gene showed two loci, one at chromosome 11 in position q13.5-q14.1, termed CLNS1A, and a second one at chromosome 6 at position p12.1-q13, termed CLNS1B. In this study, we offer a detailed characterization of the CLNS1A gene and provide the exact position (6p12) and sequence data of CLNS1B, an intronless gene 91.3% homologous to the coding region of CLNS1A.
- Find related publications in this database (using NLM MeSH Indexing)
- Amino Acid Sequence -
- Base Sequence -
- Chloride Channels - biosynthesis
- Chloride Channels - chemistry
- Chloride Channels - genetics
- Chromosome Mapping -
- Chromosomes, Human, Pair 11 -
- Chromosomes, Human, Pair 6 -
- DNA Primers -
- Exons -
- Genomic Library -
- Humans -
- In Situ Hybridization, Fluorescence -
- Introns -
- Ion Channels -
- Molecular Sequence Data -
- Open Reading Frames -
- Polymerase Chain Reaction -
- Sequence Alignment -
- Sequence Homology, Amino Acid -
- Sequence Homology, Nucleic Acid -
- Find related publications in this database (Keywords)
- I(Cln)
- swelling-dependent chloride channel
- human chromosomal localization
- RVD