Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
von Lewinski, F; Keller, BU.
Ca2+, mitochondria and selective motoneuron vulnerability: implications for ALS.
Trends Neurosci. 2005; 28(9):494-500
Doi: 10.1016/j.tins.2005.07.001
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- von Lewinski Friederike
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- Abstract:
- Motoneurons are selectively damaged in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. Although the underlying mechanisms are not completely understood, increasing evidence indicates that motoneurons are particularly sensitive to disruption of mitochondria and Ca(2+)-dependent signalling cascades. Comparison of ALS-vulnerable and ALS-resistant neurons identified low Ca(2+)-buffering capacity and a strong impact of mitochondrial signal cascades as important risk factors. Under physiological conditions, weak Ca(2+) buffers are valuable because they facilitate rapid relaxation times of Ca(2+) transients in motoneurons during high-frequency rhythmic activity. However, under pathological conditions, weak Ca(2+) buffers are potentially dangerous because they accelerate a vicious circle of mitochondrial disruption, Ca(2+) disregulation and excitotoxic cell damage.
- Find related publications in this database (using NLM MeSH Indexing)
- Amyotrophic Lateral Sclerosis - metabolism
- Amyotrophic Lateral Sclerosis - pathology
- Animals -
- Brain - metabolism
- Brain - pathology
- Calcium - metabolism
- Humans -
- Mitochondria - metabolism
- Mitochondria - pathology
- Models, Neurological -
- Motor Neurons - metabolism
- Motor Neurons - pathology
- Reactive Oxygen Species -
- Spinal Cord - metabolism
- Spinal Cord - pathology