Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Malik, R; Chauhan, G; Traylor, M; Sargurupremraj, M; Okada, Y; Mishra, A; Rutten-Jacobs, L; Giese, AK; van der Laan, SW; Gretarsdottir, S; Anderson, CD; Chong, M; Adams, HHH; Ago, T; Almgren, P; Amouyel, P; Ay, H; Bartz, TM; Benavente, OR; Bevan, S; Boncoraglio, GB; Brown, RD; Butterworth, AS; Carrera, C; Carty, CL; Chasman, DI; Chen, WM; Cole, JW; Correa, A; Cotlarciuc, I; Cruchaga, C; Danesh, J; de Bakker, PIW; DeStefano, AL; den Hoed, M; Duan, Q; Engelter, ST; Falcone, GJ; Gottesman, RF; Grewal, RP; Gudnason, V; Gustafsson, S; Haessler, J; Harris, TB; Hassan, A; Havulinna, AS; Heckbert, SR; Holliday, EG; Howard, G; Hsu, FC; Hyacinth, HI; Ikram, MA; Ingelsson, E; Irvin, MR; Jian, X; Jiménez-Conde, J; Johnson, JA; Jukema, JW; Kanai, M; Keene, KL; Kissela, BM; Kleindorfer, DO; Kooperberg, C; Kubo, M; Lange, LA; Langefeld, CD; Langenberg, C; Launer, LJ; Lee, JM; Lemmens, R; Leys, D; Lewis, CM; Lin, WY; Lindgren, AG; Lorentzen, E; Magnusson, PK; Maguire, J; Manichaikul, A; McArdle, PF; Meschia, JF; Mitchell, BD; Mosley, TH; Nalls, MA; Ninomiya, T; O'Donnell, MJ; Psaty, BM; Pulit, SL; Rannikmäe, K; Reiner, AP; Rexrode, KM; Rice, K; Rich, SS; Ridker, PM; Rost, NS; Rothwell, PM; Rotter, JI; Rundek, T; Sacco, RL; Sakaue, S; Sale, MM; Salomaa, V; Sapkota, BR; Schmidt, R; Schmidt, CO; Schminke, U; Sharma, P; Slowik, A; Sudlow, CLM; Tanislav, C; Tatlisumak, T; Taylor, KD; Thijs, VNS; Thorleifsson, G; Thorsteinsdottir, U; Tiedt, S; Trompet, S; Tzourio, C; van Duijn, CM; Walters, M; Wareham, NJ; Wassertheil-Smoller, S; Wilson, JG; Wiggins, KL; Yang, Q; Yusuf, S; Bis, JC; Pastinen, T; Ruusalepp, A; Schadt, EE; Koplev, S; Björkegren, JLM; Codoni, V; Civelek, M; Smith, NL; Trégouët, DA; Christophersen, IE; Roselli, C; Lubitz, SA; Ellinor, PT; Tai, ES; Kooner, JS; Kato, N; He, J; van der Harst, P; Elliott, P; Chambers, JC; Takeuchi, F; Johnson, AD; Sanghera, DK; Melander, O; Jern, C; Strbian, D; Fernandez-Cadenas, I; Longstreth, WT; Rolfs, A; Hata, J; Woo, D; Rosand, J; Pare, G; Hopewell, JC; Saleheen, D; Stefansson, K; Worrall, BB; Kittner, SJ; Seshadri, S; Fornage, M; Markus, HS; Howson, JMM; Kamatani, Y; Debette, S; Dichgans, M; Malik, R; Chauhan, G; Traylor, M; Sargurupremraj, M; Okada, Y; Mishra, A; Rutten-Jacobs, L; Giese, AK; van der Laan, SW; Gretarsdottir, S; Anderson, CD; Chong, M; Adams, HHH; Ago, T; Almgren, P; Amouyel, P; Ay, H; Bartz, TM; Benavente, OR; Bevan, S; Boncoraglio, GB; Brown, RD; Butterworth, AS; Carrera, C; Carty, CL; Chasman, DI; Chen, WM; Cole, JW; Correa, A; Cotlarciuc, I; Cruchaga, C; Danesh, J; de Bakker, PIW; DeStefano, AL; Hoed, MD; Duan, Q; Engelter, ST; Falcone, GJ; Gottesman, RF; Grewal, RP; Gudnason, V; Gustafsson, S; Haessler, J; Harris, TB; Hassan, A; Havulinna, AS; Heckbert, SR; Holliday, EG; Howard, G; Hsu, FC; Hyacinth, HI; Ikram, MA; Ingelsson, E; Irvin, MR; Jian, X; Jiménez-Conde, J; Johnson, JA; Jukema, JW; Kanai, M; Keene, KL; Kissela, BM; Kleindorfer, DO; Kooperberg, C; Kubo, M; Lange, LA; Langefeld, CD; Langenberg, C; Launer, LJ; Lee, JM; Lemmens, R; Leys, D; Lewis, CM; Lin, WY; Lindgren, AG; Lorentzen, E; Magnusson, PK; Maguire, J; Manichaikul, A; McArdle, PF; Meschia, JF; Mitchell, BD; Mosley, TH; Nalls, MA; Ninomiya, T; O'Donnell, MJ; Psaty, BM; Pulit, SL; Rannikmäe, K; Reiner, AP; Rexrode, KM; Rice, K; Rich, SS; Ridker, PM; Rost, NS; Rothwell, PM; Rotter, JI; Rundek, T; Sacco, RL; Sakaue, S; Sale, MM; Salomaa, V; Sapkota, BR; Schmidt, R; Schmidt, CO; Schminke, U; Sharma, P; Slowik, A; Sudlow, CLM; Ta ....
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Nat Genet. 2018; 50(4):524-537 Doi: 10.1038/s41588-018-0058-3 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Schmidt Reinhold
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-disequilibrium-score regression. Several loci exhibited distinct association and pleiotropy patterns for etiological stroke subtypes. Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Stroke risk loci were significantly enriched in drug targets for antithrombotic therapy.