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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Ruan, Y; Bally, L; Thabit, H; Leelarathna, L; Hartnell, S; Tauschmann, M; Wilinska, ME; Evans, ML; Mader, JK; Kojzar, H; Dellweg, S; Benesch, C; Arnolds, S; Pieber, TR; Hovorka, R.
Hypoglycaemia incidence and recovery during home use of hybrid closed-loop insulin delivery in adults with type 1 diabetes.
Diabetes Obes Metab. 2018; 20(8):2004-2008
Doi: 10.1111/dom.13304
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- Co-authors Med Uni Graz
- Kojzar Harald
- Mader Julia
- Pieber Thomas
- Tauschmann Martin
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- Abstract:
- Glucose excursion was assessed prior to and post hypoglycaemia to increase understanding of hypoglycaemia incidence and recovery during hybrid closed-loop insulin delivery. We retrospectively analysed data from 60 adults with type 1 diabetes who received, in a crossover randomized design, day-and-night hybrid closed-loop insulin delivery and insulin pump therapy, the latter with or without real-time continuous glucose monitoring. Over 4-week study periods, we identified hypoglycaemic episodes, defined as sensor glucose <3.0 mmol/L, and analysed sensor glucose relative to the onset of hypoglycaemia. We identified 377 hypoglycaemic episodes during hybrid closed-loop intervention vs 662 during control intervention (P < .001), with a predominant reduction of nocturnal hypoglycaemia. The slope of sensor glucose prior to hypoglycaemia was steeper during closed-loop intervention than during control intervention (P < .01), while insulin delivery was reduced (P < .01). During both day and night, participants recovered from hypoglycaemia faster when treated by closed-loop intervention. At 120 minutes post hypoglycaemia, sensor glucose levels were higher during closed-loop intervention compared to the control period (P < .05). In conclusion, closed-loop intervention reduces the risk of hypoglycaemia, particularly overnight, with swift recovery from hypoglycaemia leading to higher 2-hour post-hypoglycaemia glucose levels. © 2018 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.
- Find related publications in this database (Keywords)
- continuous glucose monitoring (CGM)
- CSII
- glycaemic control
- hypoglycaemia
- insulin delivery
- type 1 diabetes