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Obeid, R; Schon, C; Wilhelm, M; Shrestha, RP; Pilz, S; Pietrzik, K.
Response of Red Blood Cell Folate to Supplementation in Nonpregnant Women is Predictable: A Proposal for Personalized Supplementation
MOL NUTR FOOD RES. 2018; 62(4): 1700537 Doi: 10.1002/mnfr.201700537 [OPEN ACCESS]
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Co-authors Med Uni Graz: Pilz Stefan
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Abstract:: We modelled red blood cell (RBC)-folate response to supplementation and developed personalized folate supplementation concepts. The changes of RBC-folate were modelled in a time- (4 or 8 weeks) and dose- (400 μg/d or 800 μg/d folate) dependent manner. Post-supplementation RBC-folate levels were predicted from folate-loading capacities [ = measured RBC-folate - (baseline RBC-folate * RBC-survival)]. The prediction equations were validated in 119 participants. The median increase of RBC-folate was higher in the 800 μg/d than in the 400 μg/d group (275 vs. 169 nmol/L after 4 weeks, and 551 vs. 346 nmol/L after 8 weeks). Medians (interquartile range) of RBC-folate loading were [4 weeks: 299 (160) vs. 409 (237) nmol/L] and [8 weeks: 630 (134) vs. 795 (187) nmol/L] in the 400 μg/d and 800 μg/d group, respectively. The individual measured and predicted RBC-folate values (after 4 weeks/ 400 μg/d = 25 + 1.27 * baseline RBC-folate) and (after 4 weeks/800 μg/d = 65 +1.41 * baseline RBC-folate) did not differ significantly. The measured and predicted concentrations showed high agreement in the validation cohort. The models can guide nutritional recommendations in women when baseline RBC-folate concentrations are measured and the time to pregnancy between 4-8 weeks. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
Find related publications in this database (Keywords): birth defects; folate requirement; pregnancy; RBC-folate; supplementation