Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Shalom, G; Magen, E; Babaev, M; Tiosano, S; Vardy, DA; Linder, D; Horev, A; Saadia, A; Comaneshter, D; Agmon-Levin, N; Cohen, AD.
Chronic urticaria and the metabolic syndrome: a cross-sectional community-based study of 11 261 patients.
J Eur Acad Dermatol Venereol. 2018; 32(2):276-281
Doi: 10.1111/jdv.14548
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Linder Michael Dennis
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- Abstract:
- Emerging evidence suggests that chronic urticaria (CU) is associated with chronic, low-grade, inflammatory process. To evaluate the association between CU and metabolic syndrome and its components in a large community-based medical database. A cross-sectional study of CU patients and matched controls was performed. CU was defined as eight urticaria diagnoses (with each two diagnoses registered within a period of 6 weeks) from 2002 to 2012. Data regarding the prevalence of metabolic syndrome, its components and possible complications were collected. The study included 11 261 patients with CU and 67 216 controls. In a univariate analysis, CU was significantly associated with higher body mass index (BMI) and a higher prevalence of obesity, diabetes, hyperlipidaemia, hypertension, metabolic syndrome, chronic renal failure and gout. Multivariate analysis demonstrated a significant association between CU and metabolic syndrome (OR = 1.12, 95% CI 1.1-1.2, P < 0.001) and its components - obesity (OR = 1.2, 95% CI 1.1-1.3, P < 0.001), diabetes (OR = 1.08, 95% CI 1.01-1.15, P = 0.001), hyperlipidaemia (OR = 1.2, 95% CI 1.1-1.2, P < 0.001) and hypertension (OR = 1.1, 95% CI 1.1-1.2, P < 0.001). CU patients may have one or more undiagnosed components of metabolic syndrome despite their young age. Thus, appropriate targeted screening is advised. © 2017 European Academy of Dermatology and Venereology.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Body Mass Index -
- Case-Control Studies -
- Chronic Disease -
- Comorbidity -
- Cross-Sectional Studies -
- Diabetes Mellitus - epidemiology
- Female -
- Gout - epidemiology
- Humans -
- Hyperlipidemias - epidemiology
- Hypertension - epidemiology
- Israel - epidemiology
- Kidney Failure, Chronic - epidemiology
- Male -
- Metabolic Syndrome - epidemiology
- Middle Aged -
- Obesity - epidemiology
- Prevalence -
- Urticaria - epidemiology